Transition Metal-Mediated Functionaliza-tions Of Alkenes And Rh(?)-Catalyzed Selective Coupling Reaction

Quinazolinone alkaloids are widely found in natural products. The synthesis of quinazolinone nucleosides is a hotspot in the field of synthetic chemistry. We synthesized the quinazolinones and dihydroisoquinolinones diversity through the transition metal catalyzed olefin coordination tandem cyclization.In addition, we have developed the radical hydrofunctionalization of unactivated olefins by Fe(?), the hydrostyrenylation and hydrohydrazination of olefins has been achieved for the first time. What's more, We have synthesized of carbon and nitrogen heterocyclic ring through the Fe(?)-Catalyzed radical hydrofunctionalizations of olefins.At the same time, we have developed a Rh(?)-Catalyzed selective coupling of N-methoxy-1H-indole-1-carboxamides and aryl boronic acids, for divergent product formation.The main contents of this thesis include three parts:(1) The transition metal-catalyzed co-series cyclization of the alkenes, we synthesized the quinazolinones and dihydroisoquinolinones diversity (-CF3,-POPh2) through the transition metal catalyzed olefin coordination tandem cyclization.(2) Fe(?)-Catalyzed radical hydrofunctionalization of unactivated alkenes, and using olefins bearing a bromo atom tether and 2-arylidene-1H-indene-1,3(2H)-dione or benzoyl hydrazine as raw materials achieved the series of cyclization of olefin radicals.(3) Rh(?)-Catalyzed the selective coupling of N-methoxy-1H-indole-1-carboxamides and aryl boronic acids, and the indole heterocyclic compounds were synthesized by [4+2] or [4+1] cyclization.