An Au(I)-Catalyzed Rearrangement/Cyclization Cascade Toward The Synthesis Of 1,4,5,6-Tereahydrocyclopenta[b]furan

Substituted furan compounds widely exist in natural products and synthetic drugs,so the study on synthesis of substituted furan has been one of the chemical and pharmacy staff's interests for ages.The article mainly studies the series synthesis of1,4,5,6-tereahydrocyclopenta[b]furan.The method features mild conditions and extremely low catalyst dose,giving a series of 1,4,5,6-tereahydrocyclopenta[b]furan in good yield.At first,we surmised the basic process of the reaction is: butynediol experiences Meyer-Schuster rearrangement / 1,2-migration /Paal-Knorr cyclization series reaction and finally 1,4,5,6-tereahydrocyclopenta[b]furan was obtained.Then the mechanism of reaction process was verified and discussed in the paper.At present,the synthesis of 1,4,5,6-tereahydrocyclopenta[b]furan structure centre with such a low dose of catalyst has not been reported.