Development Of Optical Sensor Array With Multi-functional Materials

In the areas such as public safety, environmental monitoring and medical diagnosis,there is a widely requirement for fast reponse, sensitive and high-throughput sensorswith miniaturization. A sensor array is an artificial olfactory system based on the arrayanalysis method. On an array, information from different sensing units could becollected simultaneously, and this sensing mode is an effective way for theminiaturization of sensing device. At the moment the research of sensor array still focuson developing new sensing materials and methods. In our present work, we developedthe AuNP-based colorimetric sensor array and graphene oxide (GO)-basedtriple-channel sensing device. Also we synthesized new multi-funtional materials basedon graphene and coordination polymers, and developed new sensing methods withorganic light-emitting device. The main contents of the present dissertation are asfollows:1. A new AuNP-based colorimetric sensor array for proteins detection anddiscrimination has been developed with three reported protein aptamers as nonspecificreceptors. The proteins at relatively low level could be well distinguished with nakedeye. The sensor array can also be used for the discrimination of cancerous fromnoncancerous cells.2. The fluorescence, catalytic activity and assembly behavior of GO afterinteraction with proteins has been studied. As different proteins give distinct influencepatterns, proteins discrimination could be achieved on the triple-channel device in a‘lab-on-graphene’ approach. At the same time, a significant enhancement (~10fold) influorescence intensity is observed from GO on Ag substrate as compared to that onglass. The influence of Ag substrate metal size is investigated.3. The design and synthesis of multi-functional materials for sensor array has beendeveloped. Fe3O4nanoparticles are anchored on reduced graphene oxide, and thenanocomposites exhibit peroxidase-like activity, electrochemical and magneticproperties. Superhydrophobic zinc coordination polymers particles (CPPs) withdifferent shapes are synthesized and ZnO calcined from these CPPs also exhibitsuperhydrophobic property and good photocatalytic activity. 4. The application of light-emitting electrochemical cells (LECs) for gassensing has been studied. The sensor is realized on an improved planar light-emittingdevice, and the current and light intensity show fast and reversible responses to oxygen.The LEC sensor microarray could be used for quantitative analysis of oxygenconcentration.