| "Relationship between formulas and syndromes" is an important proposition in the formula subject, and is also the logic regularities that the formulas literature studies should follow in the researches. The entry points of this topic are from ancient tonifying formulas, and the information sources are from the Dictionary of Formulas. With frequency analysis, association regularities, fuzzy clustering and comparative analysis, and research their materia medicas, formulas, functions, syndromes to1738tonifying formulas collected.Methods:Establish the standards to filter out the tonifying formulas; and24information points (formula number, formula name, formula sources, dynasty, synonyms (source), pharmaceutical composition, dosage, usage, special frying method, special regimens, medication time, the dosage, the indicat ions, the syndrome, the symptoms, function, preparations, subtraction, taboo, notes, pro forma, square on the excerpted, clinical example, modern research. Refer to TCM clinical diagnosis term, Differential Diagnosis of Syndromes Learning, Learning the Differential Diagnosis of Clinical Symptoms, Concise Dictionary of TCM Syndrome, Chinese Herbal Medicine, Pharmacy, Chinese Dictionary, Chinese alias Dictionary, ancient and modern metrology standard tools such as books, and establish the standards of the diseases, the syndromes name, the symptoms name, the formulas functions, materia medica name, materia medica natures, materia medica efficacy, classification, etc. and according to the standard deal with their key information, and establish a database of ancient tonifying formulas, and using frequent item sets, association regularities, clustering analysis techniques relevant information in the database to analyze them totally and carefully. Also refer to the China Medical Books Summary, Song Medical Before Test, Test Medical Books, etc., and research the different characteristics of the tonifying formulas from the perspective of the origin and development of agent era.Results:(1) The analysis shows that the tonic materia medica usage accounted for56.75%in the tonifying formulas, the order among them is that tonifying qi materia medica> tonifying blood materia medica> tonifying yang materia medica> tonifying yin materia medica. It also involves other non-tonifying formula more than10categories; High-frequency spectrum of tonifying formulas mainly related to the materia medica of classic Sijunzitang, Siwutang, Liuweidihuangwan. Commonly usage of materia medica couple, materia medica group, materia medica regiment come from2to5materia medicas of the above formula. Structural analysis of the most common materia medicas is tonifying qi, blood, yang, yin, and qi and blood compatibility. Tonifying internal five zang organs/yang and qi formulas is based on the main materia medicas of tonifying qi, yang, compatible blood, yin ones; Replenishing the internal five zang organs/yin and blood formulas is based on the main materia medicas of replenishing blood, yin, compatible qi, yang ones. Tonifying both qi and blood formulas are no fundamental differences from the tonifying qi formulas and replenishing blood formulas on the compatibility, and the differences only in the qi, blood focused; Governance structure of yin and yang deficiency of both formulas to yang, blood-based, Similarly with some qi deficiency, qi and blood deficiency, yang deficiency group isotropic. Analysis syndrome and group structure of the display side, Same syndromes may correspond to different set of square structure, the same set of square structure can correspond to different syndromes. Tonifying formulas function analysis showed that the function encompasses the tonic one and non-tonic one, The former is mainly including tonifying qi, blood, yin, yang and so on, or spleen, kidney, liver, lungs, etc., Make up the heart due to the frequency of low efficacy without the analysis shows that it can be used as a complementary nerves involved; The latter mainly involves Huoxuezhitong, induce diuresis and drain dampess, astringent fine just left, temperature of the Han Tan, uneasiness of mind, blood circulation to regulate menstruation, astringent intestinal diarrhea, regulate qi, divergent cold, astringent the lung to stop cough. From the perspective of yin and yang, qi and blood of internal five zang organs classified display, The main tonifying fomulas have five types:liver and kidney tonifying one, tonifying qi and replenishing blood one, spleen and lung tonifying one, lung and kidney tonifying one, nourishing and regulating ying-blood. Dosage and usage analysis showed that Tonic soups and party pills use frequencies up to80.61%, The use of dispersants is also certain proportion, before taking more than hollow or food. One of the pills, powders commonly used in wine, salt soup, rice drink delivery service.(2) Analysis showed tonic agents attending object, The main tonifying formulas for internal diseases, in addition, commonly used in andrology, gynecology, pediatrics, surgery, ophthalmology and many other subjects. In the main deficiency syndrome kidney and heart deficiency syndrome of the internal organs are more common. The former involves the yin and yang, qi, refined loss. The latter relates to blood deficiency and qi, yin, yang, qi and blood deficiency mainly involves the spleen and stomach, lungs, kidneys. The blood deficiency involving the heart, liver, yin deficiency mainly related to kidney, liver and kidneys, heart and kidney, yang deficiency mainly related to the spleen(stomach)、kidney, yin and yang deficiency are mainly related to the kidney. The main symptoms of tonifying formulas include wasting syndrome (fatigue, loss of appetite, weight loss, etc.), related disorders (low back pain, fever, cough, etc.), and non-deficiency syndrome(vomiting, rapid pulse, etc.) categories. A combination of these symptoms two to four symptoms to some extent reflects the syndrome-correlation, such as the spleen and stomach qi deficiency symptoms related to a combination of two fatigue+loss of appetite, short of breathe, weight loss; Kidney-related symptoms with a combination of three of vertigo+tinnitus+knee soreness, backache, lumbago; qi and yin Deficiency symptoms associated with four combinations of cough, night sweats, fever or asthma. Indications for tonifying formulas diseases and syndromes correlation analysis shows consumption and qi, qi and blood, kidney qi, kidney deficiency; Back pain and kidney, yang, kidney qi deficiency; Emission and qi, kidney, yin, kidney yang, qi ang blood deficiency; Cough and Qi, yin deficiency; Impotence and kidney yang, qi deficiency; Irregular menstruation/infertility with qi and blood deficiency; Diarrhea and kidney yang, spleen deficiency; Fever and blood, qi deficiency; Abdominal pain/pox sores with qi and blood deficiency; Closely related, deafness and kidney deficiency. And kidney deficiency-related diseases and symptoms have semen disease emission (spermatorrhea, nocturnal emissions), accompanied by fatigue, sweating, tinnitus, backache:Lumbago disease-backache, back soreness, accompanied by knee soreness, knee pain, night sweats, nocturnal emission; Night sweats disease-sweats, back soreness, nocturnal emission; And spleen-related diseases have diarrhea, vomiting, loss of appetite; And lung deficiency-related diseases have a cough, sputum, wheezing. There fever diseases have fever, mouth sores, sore tongue; Edema diseases have edema, cough, asthma. It shows a combination of law between diseases and syndromes in certain conditions. Symptoms of syndrome associated with the analysis of access to relevant deficiency of yin, kidney yin, spleen and stomach. Such as deficiency of kidney yin related sweating, tinnitus, backache/back soreness, nocturnal emission, dizziness, knee soreness/knee pain; Deficiency of both the spleen and stomach related nausea, vomiting, loss of appetite and vomiting, loss of appetite, weakness, Recognizing this and the current dialectic content with good consistency.(3) Correlation analysis of disease, syndrome, or symptoms and formulas showed the materia medica associated with treatment of deficiency of qi, blood, kidney disease, syndrome, or symptoms come from Si junzi tang, Siwutang, Liuweidihuangwan. Analysis of disease syndrome-symptoms-materia medica/materia medica couple/materia medica group/materia medica regiment found its associated regularities mainly cough-qi deficiency syndrome-cough symptom-Ginseng'Ginseng+Atractylodes'Atractylodes+Ginseng+Schisandra, Impotence disease-deficiency syndrome-impotence-Aconite'Aconite+Rehmannia'aconite+Rehmannia+cinnamon.(4) Dating study of tonifying formulas showed the amount of tonifying formulas using in the Han, Jin, Northern Qi Dynasty is less. In the Song Dynasty the tonifying formulas using achieved rapid development, Jin into the bottom, Yuan and Ming gradually return to growth. In the Qing Dynasty the tonifying formulas using grew to new heights. Materia medica on the part of the ancient tonifying formulas and the amount of compatibility study shows that the materia medica of common tonifying formula is concerned to8ones, Its wholly-side single-serving doses of60to120grams. Tip clinical taste neither too much nor tonifying formulas overdose, according to the key lies in the efficacy card compatibility, fight the pathogenesis.Conclusion:Tonifying formulas are based on tonifying materia medica and multi-compatibility of other non-tonic one. The core materia medica of tonifying formulas mostly come from classical ancient tonifying formulas, especially qi and blood compatibility of the drug at the key; Tonifying formulas involved multidisciplinary disease, and the emphasis of yin, yang, qi and blood deficiency syndrome. The disease and syndrome or syndrome and symptom in the indications of tonifying formulas has a certain correspondence relationship, and also has the same certain correspondence or combination regularity between the tonifying formulas and syndrome or symptom of the disease.Based on the tonifying formulas of ancient Chinese medicine literature collection and building a database on using data mining techniques from multiple dimensions on the side of the drug-groupeffect-syndrome the law permits were exploratory. Initially gained experience tonic prescription range of applications, compatibility characteristics medication, dosage and usage experience, the regularities about the formulas structure based on qi, blood and yin, yang or five zang organs deficiency syndrome, the categories of tonifying formulas based on materia medica function, the correspondence relationship between disease, syndrome, symptoms and formulas, materia medica.The results of this study enriches the current formulas concerning tonifying formulas content; Normalized text processing side created a database for the tonifies of ancient Chinese medicine research information provided a foundation; Data mining can also be the result of clinical medicine, teaching and research to provide a reference. |
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