| Objective: By heat treating complex renal blood stasis purpura nephritisclinical research, clinical efficacy and safety of drugs, so as to clinicaltreatment of children with allergic purpura nephritis provide more effectivetreatments.Methods: The clinical observation of selected cases were diagnosed as purpuranephritis (hematuria and/or proteinuria) in children, using the principlesof randomized60patients enrolled were randomly divided into traditionalChinese medicine treatment group (less referred to the treatment group) andtriptolide group (hereinafter referred to as the control group) two groups, eachof30cases. Both groups received the same basic treatment, including attentiondesensitization diet, avoid strenuous exercise, pay attention to prevent colds,while both oral VC, VE, rutin, dipyridamole and other basic drugs, the controlgroup on the basis of the treatment of oral TWP tablets,1mg/kg d,3timesafter oral administration; basic treatment in the treatment group, while theexperience of using the tutor prescription Fushenning decoction. The two groupsare one month of a course of treatment, observation of three courses. Aftertreatment, the clinical effect, and all of the cases did not fall off athree-month follow-up observations, summarize clinical outcomes.Results:1.General information before treatment, clinical symptoms, signs, symptom score,urine red blood cell count,24hours and the amount of protein and chemicalexamination of other selected indicators observed no significant differencesin the statistical analysis (P>0.05), comparable.2.before and after treatment efficacy disease markedly effective rate and totaleffective comparison, the results show: the treatment group markedly effectiverate was64.3%, total effective rate was92.9%, markedly effective rate was33.3% in the control group, the clinical The total effective rate was70.4%, comparedthe two groups, both in the markedly effective rate or the total clinicalefficiency, there were significant differences (P <0.05). Statistical analysisshows that the treatment group than the control group.3.before and after treatment syndromes total credit comparison, the resultsshowed that: the treatment group treatment score was11.63±2.42, aftertreatment score was2.58±1.62, control group treatment score was11.37±2.61, after treatment Points to6.62±2.41, both groups after treatmentcompared with before treatment, there was a significant difference (P <0.05),indicating that the treatment group and the control group were symptom scoredecreased significantly after treatment than before treatment. After treatment,the total score of TCM and the control group after treatment, TCM total score,compared with a significant difference (P <0.05), indicating that the treatmentgroup improved TCM superior to the control group.Before and after treatment TCM syndromes markedly effective rate and totaleffective comparison, the results show: the treatment group markedly effectiverate was85.7%, total effective rate was100.0%, markedly effective rate was51.9%in the control group, the clinical The total effective rate was81.5%,compared the two groups, both in the markedly effective rate or the total clinicalefficiency, the statistical comparison, there were significant differences (P<0.05). Statistical analysis shows that the treatment group than the controlgroup.4.red blood cell count in urine before and after treatment comparison, theresults show: the two groups after treatment compared with before treatment,there was a significant difference (P <0.05), indicating that the treatment groupand the control group were significantly lower red blood cell count in urineafter treatment than before treatment. After treatment of urinary red blood cellcount after treatment with the control group compared to urinary red blood cellcount was significant difference (P <0.05), indicating that the treatment grouppurpura nephritis urinary red blood cell count than the control group. Before and after treatment of24-hour urinary protein excretion comparison, theresults show: the two groups after treatment compared with before treatment,there was a significant difference (P <0.05), indicating that the treatment groupand the control group,24-hour urinary protein excretion were significantlydecreased after treatment than before treatment. However, the treatment groupof24-hour urinary protein excretion compared with the control group aftertreatment,24-hour urinary protein excretion showed no significant difference(P>0.05), indicating that the treatment group purpura nephritis in24-hoururinary protein excretion there was no obvious advantage.In this clinical observation, the treatment group to reduce urinaryβ2-microglobulin, urinary albumin, immune globulins IgA, IgG and reducedplatelet count, improve blood clotting function were significantly better thanthe control group, the statistical analysis, there was a significant difference(P <0.05).5.were observed recurrence rate after treatment, the results show: the treatmentgroup follow-up recurrence rate was5.6%in the control group, the recurrencerate was33.3%follow-up, there is a statistically significant difference (P<0.05); patients in both groups children during treatment, the treatment groupnumber of cases of adverse events was significantly lower than the control group,two groups, there is a statistically significant difference (P <0.05).Conclusion:1.Clinical manifestations hematuria and/or proteinuria dominated purpuranephritis through clinical TCM is hot and humid stasis type by using traditionalChinese medicine decoction self Fushenning has better reduce urinary proteinin red blood cells and the role of urinary.2.Fushenning soup can significantly improve heat stasis type allergic purpuranephritis TCM clinical syndromes, and no significant side effects. ButFushenning Tang role in reducing urinary protein chip TWP compared with noobvious advantage, although Tripterygium glycosides tablet better to reduce the role of protein in the urine, but in purpura renal hematuria syndrome symptomsand clinical medicine not as good as traditional Chinese medicine complex kidneysoup, there are certain side effects.3.by observing complex Decoction on purpura in children before and aftertreatment of renal immunoglobulin IgA, IgG, IgM, and platelet count andcoagulation function, suggesting that the mechanism of the disease may be relatedto immune function, hypercoagulable states and other factors, However, thespecific role of how and whether there are other mechanisms need to be in thefuture further research. |
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