Academic And Experimental Research On MCF-7Breast Cancer In Nude Mice With Principle Of Strengthening Qi And Tonifying Yang

Based on the theory of Traditional Chinese Medicine (TCM), combined with the Professor Zhang Yonghong academic ideas and experience in treatment of breast cancer, the thesis studies the theory of breast cancer treatment through the view of TCM and probe the influence of Strengthening Qi and Tonifying Yang decoction. Meanwhile the article collects and synthesizes the literature report to analyze the mechanism of Strengthening Qi and Tonifying Yang decoction. The thesis consists of two parts:Part one is about reference of status of the cancer especially the breast cancer including China and Western regions. And the part is also to sum up Western medicine and TCM study. In this part the article reviews the status of experiment and clinical research for breast cancer in order to enlarge knowledge, probe out new trends, elucidate the existent question and view new research ideas, at the same time, the paper emphasizes the importance and necessary of deeper research. This part is also about research of basic theory which focuses on physiology and pathology of breast cancer and the relationship with other organs and discuss the etiology, pathogenesis and treatment methods. The article considers that the location of breast cancer lies in breast, mainly affect liver, spleen and kidney. The pathological character is Ben asthenia and Biao sthenia and the pathological factor is qi and blood deficiencies, chong and ren disorders, qi stagnation, cold coagulation, blood stasis, phlegm stagnation, and cancer toxin. Qi and Yang deficiencies and cold coagulation are pathogenic basis of breast cancer, phlegm stasis is the primary pathologic change, and asthenia of Qi and Yang is the internal pathogenesis. The article also put forward treatment principle of invigorating the Qi and Yang, and eliminating phlegm and damp as the basis.Part two of this paper is about experimental research which studies the effect of Strengthening Qi and Tonifying Yang on the animal model of MCF-7breast cancer. The experiment studies the Chinese herbs, CTX, and combined treatment. The mice were killed after10days treatment, and the symptoms and effect were observed. The results show us that the Strengthening Qi and Tonifying Yang decoction can improve the symptoms such as the appetite and spirit, enhance the anti-cancer function, and increase the tumor suppressor index. From the observation of symptoms, no toxin are discovered from the herbs decoction. But the tumor suppressor rate is weaker than CTX. Scanning fluorescence microscopy shows Chinese herb group’s tumor cell Nuclei chromatin condensation and nuclear fragmentation. Microvillus are smaller and there are hiatus on the surface of the tumor cell which may be caused by the effect of Chinese herbs anti-tumor function.