Research On Alcoholic Liver Disease Though Traditional Chinese Medicine Syndrome

Syndrome is the core and most important part of traditional Chinese medicine, disease-location and disease-character are essential to syndrome. When a syndrome is composed of single disease-location and disease-character, it is called basic syndrome. Having devoted to the study for tens of years, my tutor have constructed a systematic, developmental, dialectical, five viscera centered five-viscera syndrome system. This issue applied the syndrome pattern and combination law of her new five-viscera syndrome system to alcoholic liver disease. By the methods of literature research and epidemiology investigations on clinical case reports, this issue intended to regulate the name, location, characteristic, basic syndrome and compound syndrome of alcoholic liver disease, emphasized the principles of "from symptoms to syndromes" and "combination of disease and syndrome differentiation", constructed the syndrome thinking model and principle of alcoholic liver disease. The fundamental principle and general law of alcoholic liver disease in traditional Chinese medical was revealed on whole. Meanwhile modern scientific research methods are applied. The syndromes combined effective ideas and methods was proposed. The new idea was kept that the traditional value of TCM syndrome combination is closely integrated with clinical. Therefore the combination of disease and syndrome differentiation dialectical treatment of alcoholic liver disease was much more flexible, accurate, easier to grasp, and more in line with the clinical disease and syndrome differentiation thought. It would play an important guiding role in improving the level of clinical diagnosis and treatment.The first part is about theoretical research. By a systematic study on literatures, this part summed up researches by ancient and modern doctors on names, causes, mechanism, syndrome and classification, nature of syndrome of alcoholic liver disease. Ancient doctors classified alcoholic liver disease as for instance "alcoholic injury","drinking disease","disease with improper drink","alcoholic dyspepsia","accumulation","alcohol addiction","alcoholic jaundice","alcoholic tympanites", etc., there were no unified and definite disease-name. And they said that the cause was hot and humid phlegm the toxin, the location was liver system based and the spleen, stomach and renal system also hurt.They distinguish the patterns and syndromes quit different. Modern medicine deems that alcoholic liver disease relate to ethanol and its metabolite poison, cytokine, iron, gene etc.The second part is about research on syndrome regulation of alcoholic liver disease. Through researches on disease-names in TCM,"alcoholic dyspepsia" was proposed for the disease-name of alcoholic liver disease in TCM. The cause and mechanism was re-illuminated, it was specified that alcoholic toxicity is the major cause. Improper diet, disorder of emotions, poison perching are major factors of how alcoholic liver disease happened and developed, and physique is another very important factor. Healthy deficiency and poison excess is the foundation of the disease. The basic pathogenesis is alcohol poisoning intrusion, dampness and heat in liver and gallbladder.By the method of clinical epidemiologist research, we collected713clinical cases, and using SPSS to do cluster analysis and principal component analysis. We summed up the syndrome of diagnosis data, for instance, syndrome and tongue vein, explored the distribution of disease-position and disease syndrome factor, used the association rules to study relationship between the syndrome and drinking history, liver function, blood-fat. We constructed an "alcoholic liver disease Syndrome Diagnosis Information List", regulated disease-position, disease syndrome factor, and characteristic, researched into basic syndrome and compound syndrome combination laws.Researches have revealed that alcoholic liver disease is located in liver, relates to gall, spleen, stomach, kidney. Its main characteristic includes noxious dampness, fire heat, and also turbid phlegm, blood stasis, stagnation of qi, deficiency of qi, deficiency of yin, deficiency of yang, water retention etc.Its basic syndromes include liver heat syndrome, liver damp syndrome,, bile heat syndrome, live-depression syndrome, spleen-qi deficiency syndrome, gastric qi stagnation, spleen dampness, liver stagnation syndrome, liver sputum syndrome, liver yin deficiency syndrome,kidney yin deficiency syndrome, spleen stasis syndrome, spleen yang deficiency syndrome, kidney yang deficiency syndrome. Its compound syndromes are usually liver and gallbladder damp-heat syndrome, liver depression and spleen deficiency syndrome, incoordination between the liver and stomach, the liver and spleen blood stasis, intermingled phlegm and blood stasis, liver kidney yin deficiency, spleen deficiency wet accumulation syndromes, spleen kidney yang deficiency syndrome. It is also considered in pattern of syndrome that drinking history, liver function, blood-fat,syndromes.The thesis investigated the syndrome regulation of alcoholic liver disease, made it clear that the name, location, disease syndrome factor characteristics, basic syndrome and compound syndrome of the disease. The thesis followed the principle of "from symptoms to syndromes" in traditional Chinese medicine, and clarified the dialectical thought of "five viscera syndrome differentiation system "as the core, exposed dialectical systematicness and expansibility, stability and particularity of syndrome, thus in accordance with the dialectical thought of clinical alcoholic liver disease.