The Study On "Syndrome" Of NSCLC By Thoracoscopic Technique

Objective:To study the relationship of the traditional Chinese medicine (TCM)"syndrome" in correlation with general body status, life quality, histopathology, metastasis, drug tolerability, and prognostic assessment in non-small cell lung cancer patients. We anticipated that these correlations of the "syndrome" differentiation will help to provide the scientificity and feasibility evidences of the internal and external inspection in lung cancer patients.Methods:60cases of non-small cell lung cancer patients were divided into two groups,30with qiyin deficiency and30with qi stagnation. Collection of TCM symptom score, Karnofsky score (KPS、ZPS), quality of life (FACT-L) score were all recorded one day before operation in both groups. The lung tumor specimens were resected by using thoracoscopic (VATS) technique and send for histopathology, VEGF, P-gp study to investigate the variations between the two groups. The correlations of the TCM "syndrome" differentiation in both groups of patients were recorded and statistically compared.Results:TCM symptom score in the patients is higher in qiyin deficiency compared with those with qi stagnation (P<0.05), KPS score is lower in qiyin deficiency but higher ZPS score was found as compare to group with qi stagnation (P<0.05). As for FACT-L score, qiyin deficiency group showed higher and significant than the latter,(P<0.01). Comparing between the gross appearances and histologic changes, tumour tissue in patients with qiyin deficiency seems pale and diffuse infiltrative pattern and tissue in qi stagnation seems more congested and inflammatory changes. Both the VEGF、P-gp data in qiyin deficiency is higher than the patient groups in qi stagnation (P<0.05).Conclusion:TCM "syndromes "of non-small cell lung cancer showed some relations with patients’general body conditions; life quality, histopathology, metastasis and drug tolerability. Patients with qiyin deficiency might be one of the poor factors which will further affect the treatment and prognosis in lung cancer patients.