The Effect Of Dual-task Interference On Hand Flexibility Of Patients With Parkinson’s Disease Carrying The LRRK2Gene Mutation And Hemi-Parkinson’s Disease

Part1. The effect of dual-task interference on hand flexibility of patients with Parkinson’s disease carrying the LRRK2gene mutationObjective:To observe the changes of hand flexibility of patients with PD carrying the LRRK2gene mutation and the situation of dual-task interference.Methods:Patients with PD were distributed into two subgroups:LRRK2(+) PD group and non-LRRK2(-) PD group; healthy controls were distributed into two subgroups: LRRK2(+)control group and LRRK2(-) control groups. The first task was Purdue pegboard test. The second task was to perform serial7subtractions. Single-task tests and dual-task test were performed respectively to record the numbers of nails inserted with dominant hand, non-dominant hand and both hands within30seconds and the number of correct response.Results:The UPDRSⅢ score of examinees in LRRK2(+)PD group was significantly higher than that of examinees in LRRK2(-) PD group (P<0.05). The number of nails inserted within30s by patients with PD was significantly lower than that by controls (P<0.05). Compared with control group, indicators of patients with PD, such as NVD, NVND and NVB, were significantly different (P<0.05). The difference of correct response number within30s of patients with PD was significantly correlated with UPDRSIII score (P<0.05).Conclusion:The hand flexibility of patients with PD obviously decreased. When both tasks were performed, the ability obviously decreased in the second cognitive task, especially in the LRRK2(+)PD group. Part2. The effect of dual-task interference on hand flexibility of patients with hemi-Parkinson’s diseaseObjective:To observe the changes of hand flexibility of patients with hemi-PD and the situation of dual-task interference.Methods:163subjects were distributed into two subgroups:PD group and control group; PD group were distributed into two subgroups PD-left group and PD-right group. The first task was Purdue pegboard test. The second task was to perform serial7subtractions. Single-task tests and dual-task test were performed respectively to record the numbers of nails inserted with left hand,right hand and both hands within30seconds and the number of correct response.Results:There were no significant dirrerence in the number fo patients、age、gender、 HAMD、UPDRS、H-Y between PD group and control group. The UPDRSⅢ score of examinees in LRRK2(+)PD group was significantly higher than that of examinees in LRRK2(-) PD group (P<0.05). The number of pegs inserted within30s by patients with PD was significantly lower than that by controls (P<0.05). The pegs variation has no significantly different between PD group and control group (P>0.05). The difference of correct response number within30s and the number variation of patients with PD was significantly different (P<0.05).Conclusion:The hand flexibility of patients with hemi-PD obviously decreased on affected hand. When both tasks were performed, the ability obviously decreased in the second cognitive task on both on affected hand and no on affected hand.