Expression Of T-cadherin And VE-cadherin In Adenomyosis And Endometriosis

Objective:To observe the expressions of T-cadherin (T-cad) and VE-cadherin (VE-cad) proteins in adenomyosis (AM) and endometriosis (EM), and investigate the relationship between the two proteins.Methods:The expression level of T-cad and VE-cad in the ectopic and eutopic endometrium of AM group, the ectopic and eutopic endometrium of EM group, the ovary ectopic, myometrium ectopic and eutopic endometrium of EM-AM-combined group and the control group was detected via immunohistochemistry method (SP two-step), and analysis the differential expression of the two proteins in all kinds of endometrium and do the correlation studies.Results:1. The T-cad expression in the ectopic endometrium of the AM group is significantly down-regulated compared to the eutopic endometrium of the same group (6.67%compared to11.11%, P<0.05); and both are down-regulated compared to the control group (6.67%and11.11%compared to37.78%, P<0.05). The T-cad expression in the ectopic endometrium of the EM group is up-regulated compared to the eutopic endometrium of the same group (24.44%compared to4.44%, P<0.05); and both are down-regulated compared to the control group (24.44%and4.44%compared to37.78%, P<O.05). The T-cad expression in the myometrium ectopic endometrium of the combined group is down-regulated compared to the ovary ectopic endometrium of the same group (2.22%compared to6.67%, P<0.05), and both are down-regulated compared to the eutopic endometrium of the same group (2.22%and6.67%compared to11.11%, P<0.05), and in the eutopic endometrium of the combined group the T-cad expression is down-regulated compared to the control group (11.11%compared to37.78%, P<0.05). The T-cad expression in the eutopic endometrium of AM group, EM group, combined group have no statistical difference (P>0.05), but lower than the control group.2. The VE-cad expression in the ectopic endometrium of the AM group is up-regulated compared to the eutopic endometrium of the same group and the control group (71.11%compared to26.67%and17.78%, P<0.05); and the latter one the VE-cad expression has no statistical difference compared to the control group (26.67%compared to17.78%, P>0.05). The VE-cad expression in the ectopic endometrium of the EM group is up-regulated compared to the eutopic endometrium of the same group and the control group (64.44%compared to28.89%and17.78%, P<0.05); and the latter one the VE-cad expression has no statistical difference compared to the control group (28.89%compared to17.78%, P>0.05). The T-cad expression in the ovary ectopic endometrium of the combined group is up-regulated compared to the myometrium ectopic endometrium of the same group (68.89%compared to42.22%, P<0.05), both are up-regulated compared to the the eutopic endometrium of the same group (68.89%and42.22%compared to33.33%, P<0.05), and the eutopic endometrium of the combined group has no statistical difference compared to the control group (33.33%compared to17.78%, P<0.05). The VE-cad expression in the control group and eutopic endometrium of AM group, EM group, combined group have no statistical difference (P>0.05).3. The expression level of T-cad in the ectopic endometrium of EM group and the ovary ectopic endometrium of combined group has significant correlation with the r-AFS stages (P<0.05). There is no significant correlation between the expression level of VE-cad and r-AFS stages in all groups (P>0.05).4. There is no significant correlation between the expression level of T-cad and VE-cad in all groups (P>0.05). Conclusion:1. Compared with the control group, the expression level of T-cadherin is lower in both AM and EM eutopic endometrium, indicated the eutopic endometrium of AM and EM have already had pathological changes, and got some kind of invasive ability.2. The high expression of VE-cadherin in the ectopic endometrium of AM and EM may be involved in the mechanism of the angiogenesis in the AM and EM ectopic endometrium.3. The expression level of T-cadherin in the eutopic endometrium of the three groups had no statistical difference, indicates though the mechanism of AM and EM are different, the process of the immigration and invasion may be the same.4. In this research, T-cadherin and VE-cadherin have foud no significant correlation in this research, and they may palyed significant roles together through a sequencing way in the mechanism of AM and EM.