The Correlations Between C-fos Expression And Patients’Clinicopathological Factors And Prognosis In Gastric Cancer And The Explortory Use Of NRS-2002to Screen The Perioperative Nutrition-risk In Patients With Gastric Cancer

Objective:To evaluate correlations between c-fos expression and patients’ clinicopathological factors and prognosis in gastric cancer.Methods:A total of58patients with gastric cancer underwent surgical resection from Jun2002to Jan2003were included. Expression of c-fos in tumor and para-tumor tissues was determined by immunohistochemistry. The relationship between c-fos expression and clinicopathological and prognostic variables were evaluated.Results:The expression ratios of c-fos in tumor and para-tumor tissues were67.2%and63.8%, respectively. Simultaneously positive or negative c-fos expression in tumor and para-tumor tissues occurred in44patients (75.9%). Tumors with positive expression of c-fos in tumor tissues carried smaller size and lower rate of full-layer infiltration. Univariate analysis showed that patients with positive c-fos expression in tumor tissues had significantly prolonged overall and tumor-free survival, compared with those with negative expression. Cox regression test revealed that c-fos expression in tumor tissues was of potential independent prognostic implication. Expression of c-fos in para-tumor tissues was not correlated with clinicopathological variables and patient prognosis.Conclusions:Our data demonstrated that c-fos was positively expressed in both tumor and para-tumor tissues. Besides, c-fos expression in tumor tissues was consistent with that in para-tumor tissues. The findings indicated that c-fos might be involved in tumorigenesis of gastric cancer. Tumors with c-fos positive expression were of less progression extents, suggesting the inhibitory effect of c-fos in progression of gastric cancer. Finally, c-fos positive expression in tumor tissues was associated with favorable prognosis, showing its potential as a molecular prognostic factor. Objective:The aim of this study was to evaluate the rate of nutrition risk in patients with gastric cancer, colonorectal cancer and cholelithiasis by NRS-2002, to assess the correlations between nutrition risk and nutrition related hemological levels, applications of nutrition support and health economical indexes.Methods:In this prospective study, patients in general surgery department were included from Oct2008to Jun2009,50cases of gastric cancer, colonorectal cancer and cholelithiasis, respectively. Patients received NRS-2002nutrition risk screening at the admission. Data aslo was recorded on nutrition related hemological levels, applications of nutrition support and health economical indexes.Results:The average rate of nutrition risk in gastric cancer was68%, higher than those of colonorectal cancer and cholelithiasis (standardrized rate of nutrition risk30.3%and20.9%, respectively). The average level of total serum protein of gastric cancer patients at nutrition risk (69.41g/L) was lower than that at no nutrition risk (72.38g/L). Compared with those without preoperation nutrition support, the average length of hospital stay, post operation days, total expenses, and drug expenses didn’t show any stastic significance in patients received preoperation nutrition support.Conclutions:Patients with gastric cancer had a relatively higher rate of nutrition risk. Nutrition risk in gastric cancer correlated with decrease levels of total serum protein. Preoperation nutrition support didn’t increase the in-patient length and medical expenses. Those might contribute to the medical care policy making for health economy.