Impetus For Gastrointestinal Acute Brain Injury Animals

Objective:to investigate the change of gastrointestinal motility in the state of acute severe head injury and the change of related factors.Methods:50Wistar rats were randomly divided into5groups with10each:Blank group,6hours after trauma group,24hours after trauma group,48hours after trauma group,72hours after trauma group. Make severe head injury model with Marmarou’s modeling. Then at the predicted time check the gastrointestinal transmission rate, concentration of VIP,GAS and MTL in the pylic blood, the morphous, number and structure of ICCs distributed in the small intestine muscle layers.Results:1.6h-72h after severe head injury, in trauma groups,a function disturbance of gastrointestinal motility could be observed(p<0.001).2. In all trauma groups VIP went up significantly (p<0.05), and GAS went up significantly (p<0.05) in24hour after trauma group, and MTL went up significantly (p<0.05) in the24hour after trauma group. In different groups there were positive or negative correlations significantly between the gastrointestinal transit ratio and hormones, as well as among different hormones.(p<0.05)3. with immunohistochemical method and in TEM ICC-MY�'�ICC-DMP were both observed, but no obvious differences were observed between blank group and trauma groups.Conclusion:6h after severe head injury, a function disturbance of gastrointestinal transit could be observed and wouldn’t recover until72h. And gastrointestinal hormones changed significantly. But no obvious differences were observed in ICC among different groups.