LH And LH / FSH In Patients With Polycystic Ovary Syndrome Chinese Characteristics, Factors And Diagnostic Significance

Objective To investigate the characteristics of luteinizing hormone (LH) and the ratio of luteinizing hormone to follicle stimulating hormone (LH/FSH) in women with PCOS in China, and evaluate the value of them in diagnosis of polycystic ovary syndrome.Methods The studied group consisted of209patients who has one item of2003Rotterdam criteria at least,167of which are diagnosed as PCOS. A total of61healthy controls are recruited. Compare average values of all observed data between three groups, and divided all groups by body mass index, testosterone and HOMA-IR to analyze the relationship of LH and these factors. Diagnose PCOS by LH/FSH and evaluate the sensitivity and specificity, and receiver operating characteristics (ROC) curve are explored to on the value of diagnosis PCOS.Results1. The value of LH and LH/FSH in PCOS is generally higher than non-PCOS patients and the normal population.2. LH and LH/FSH values decreased as BMI increased, while increased as testosterone increased, but do not change as HOMA-IR changes.3. Without other influencing factors, LH and LH/FSH values are still generally higher than non-PCOS patients and the normal population.4. The sensitivity and specificity of diagnosing PCOS as LH/FSH≧1are92.22%and52.38%respectively, while the specificity of patients with hyperandrogemia (HA) or polycystic ovary (PCO) can be increased to80.95%or78.57%.5. The sensitivity and specificity of JSOG criteria are88%and100%, similar with Rotterdam criteria;6. When using LH/FSH to diagnosis PCOS by Rotterdam criteria and JSOG criteria, areas under ROC curve are0.746and0.942, which are higher than using T(0.638and0.756respectively).7. Non-PCOS patients with LH/FSH≧1.22are more close to PCOS.Conclusions Increased LH and LH/FSH are the inherent characteristics in PCOS patients. Testosterone is the positive influential factor while obese is the negative factor, and testosterone is more powerful. LH/FSH provides the significant value in the diagnosis of PCOS among patients who has one item of2003Rotterdam criteria at least, especially for whom with HA or OD.