Research On The Correlation Between Liver Dysfunction’s Performance Characteristics Of Cirrhosis And Micro Index

Liver controlling dispersion is an important function of liver in the theory of TCM. The function plays an important role in the process of development of cirrhosis.This paper includes literature and clinical study. Through the tansformations of the symptoms and micro index of cirrhosis, find the correlation between them. Then find the symptoms and micro index of liver dysfunction of TCM to explain the theory of liver controlling dispersion.Part1Literature StudyObjectiveTo analysisi the characteristics of TCM syndrome differentiation and the correlation between common TCM syndromes of cirrhosis and liver function indicators based on neoteric literature.Methods1Select effective cases of hepatitis cirrhosis according to the inclusion criteria on the basis of review of literatures published between1991and2010in the databases.2Select effective clinical reports of cirrhosis according to the inclusion criteria on the basis of review of literatures published between1991and2010in the databases.3To summarize the common symptoms, syndromes and the TCM prescriptions and medicine of the hepatitis cirrhosis cases.4To investigate the correlation between common TCM syndromes of cirrhosis and liver function indicators.Results1Common symptoms in the compensated cirrhosis are pulse string, hypochondriac pain, weakness, greasy coating, abdominal distention, thin coating, pulse thready, yellow fur, white fur and etc. In the decompensated cirrhosis are abdominal bulge, oliguria, pulse siring, ascites, edema of lower limbs, abdominal distention, pulse thready, weakness and etc. Hypochondriac pain, abdominal distention, anorexia and loose stool which arc the manifestations of liver dysfunction appear in both periods of hepatitis cirrhosis.2Common syndromes in the compensated cirrhosis arc depressed liver and deficient spleen, Qi stagnation and blood stasis, damp-heat, liver and kidney deficiency, liver depression and blood stasis and etc. In the decompensated cirrhosis are water and dampness retention, Qi stagnation and blood stasis, depressed liver and deficient spleen, damp-heat, spleen-kidney-yang deficiency and etc. The syndrome of depressed liver and deficient spleen are appearing in the two periods and obvious in compensated cirrhosis.3Common syndrome key factors in the compensated cirrhosis are liver, spleen, kidney, blood stasis, Qi stagnation, Qi deficiency, damp-heat and yin deficiency. In the decompensated cirrhosis are spleen, liver, kidney, blood stasis, water retention, Qi stagnation, damp obstruction and Qi deficiency. The syndrome key facors of Qi stagnation and blood stasis are results from qi-movement disturbance and qi-blood imbalance.4Taking the common occurrence frequency of equal to or greater than20%as the inclusion criteria, the main components of Chinese herb compound for compensated hepatitis cirrhosis were Baizhu(rhizome), Danshen(salvia), Baishao(radix paeoniae alba), Danggui(angelica), Chaihu(radix bupleuri), Yujin(turmeric), Biejia(turtle shell), Dangshen(codonopsis pilosula), Fuling(poria cocos) and Taoren(peach kernel), and for decompensated hepatitis cirrhosis were Baizhu(rhizome), Fuling(poria cocos), Dafupi(areca peel), Danshen(salvia), Zexie(rhizome alismatis), Huangqi(bupleurum), Zhuling(agaric), Biejia(turtle shell), Danggui(angelica) and Dangshen(codonopsis pilosula). The principle of treatment is reliefing liver for smooth basing on the theory of liver controlling dispersion.5The hepatic depression syndrome patients had light abnormal liver function. Their liver function indicators of ALT, AST, ALP, GGT and TBA go up somehow. Conclusions1There are some syndromes and symptoms caused by liver-qi stagnation in both compensated and decompensated cirrhosis and obvious in compensated cirrhosis.2There is some association between liver dysfunction syndromes of cirrhosis and the liver function indicators.Part2Clinical StudyObjectiveThrough the investigation of clinical symptoms and micro index of hepatitis cirrhosis, comparative analysis, factor analysis and correlation analysis, discuss the correlation between liver dysfunction’s performance characteristics of hepatitis cirrhosis and micro index.Methods1The national multi-centers and big sample clinical epidenmiology investigation of hepatitis cirrhosis was developed on strice quality control. 2Established the database of clinical epidemiology investigation of hepatitis cirrhosis.3Through methods of comparative analysis, analyze the symptoms and micro index difference between compensated and decompensated cirrhosis.4Through methods of factor analysis and correlation analysis, analyze the correlation between liver dysfunction’s performance characteristics of hepatitis cirrhosis and micro index.Results1Common symptoms in the compensated cirrhosis are weakness, liver palms, anxiety and irritability, gloomy complexion, soreness and weakness of waist and knees, dry mouth and pharynx, fatigue, stomach distention and etc. In the decompensated cirrhosis are weakness, gloomy complexion, liver palms, fatigue, abdominal distention, stomach distention, deep yellow urine, dry mouth and pharynx and etc. Rib-side distention, sighing, choking sensation in chest, depression, anxiety, abdominal distention and anorexia which are the manifestations of liver dysfunction appear in both periods of hepatitis cirrhosis.2Some symptoms have significant differences in compensated and decompensated cirrhosis. They are fatigue, weakness, laziness to speak, emaciation, fever, edema, flushing, gloomy complexion, rib-side distention, hypochondriac pain, stomach distention, abdominal distention, abdominal pain, anorexia and etc. The symbol symptoms of stagnation of liver qi and sentiment abnormality are obvious in compensated cirrhosis. The symbol symptoms of incoordination between spleen and stomach are obvious in decompensated cirrhosis.3Most of the micro index has significant differences in compensated and decompensated cirrhosis because of the illness growing worse sunch as the the index of hcmatopoicsis, coagulation, liver function, dyslipidcmia, renal function, electrolyte disturbance and etc. which are related to the manifestations of liver dysfunction.4The liver dysfunction is related to the index of hematopoiesis, coagulation, liver function, dyslipidemia, renal function, electrolyte disturbance and etc.Conclusions1The stagnation of liver qi and sentiment abnormality of compensated cirrhosis is more obvious.The incoordination between spleen and stomach of decompensated cirrhosis is more obvious.The different liver dysfunction’s performance characteristics of hepatitis cirrhosis has different pathophysiological basis.2The liver dysfunction’s performance characteristics of hepatitis cirrhosis are mainly stagnation of liver qi, sentiment abnormality and incoordination between spleen and stomach. The three parts respectively have relationship with different micro index.