Predictive Value Of Fibrotouch Combined With FIB-4 Index In Complications Of Liver Cirrhosis

Objective: To evaluate the predictive value of Fibrotouch combined with FIB-4 index in complications of liver cirrhosis.Methods: From June 2015 to February 2016, the liver cirrhosis patients in our hospital outpatient or inpatient department were collected for research. Fibrotouch was used to measure the liver stiffness value(LSM). serum alanine aminotransferase(ALT), aspartate aminotransferase(AST) and platelet(PLT) were deteced and all patients underwent abdominal color Doppler or other imaging tests. Then, calculated FIB-4 index and Child-Pugh score. The LSM in liver cirrhosis patients with different liver function Child-Pugh was analyzed, the difference of LSM between patients with compensted cirrhosis or decompensted cirrhosis were compared. The difference of LSM in single complication or multiple complications in patients with cirrhosis were compared. Compare the FIB-4 index in different liver function(Child-Pugh grade), compare the FIB-4 index in different patients with compensated cirrhosis or decompensted cirrhosis, and compare the FIB-4 index in single complication or multiple complications in patients with cirrhosis.Evaluate the value of Fibrotouch and FIB-4 index separately or in combination in the diagnosis and prediction of liver cirrhosis complications. The sensitivity, specificity and ROC curves were used to evaluate the results.Results: LSM values are different in patients with different liver function(Child-Pugh grade), the higher Child-Pugh grade, the more LSM values and FIB-4 index, the difference was statistically significant(P < 0.001). LSM values and FIB-4 index were different in different patients with compensated cirrhosis or decompensted cirrhosis, the difference was statistically significant(P < 0.001). LSM values and FIB-4 index were higher in multiple complications patients than in single complication patients, the difference was statistically significant(P < 0.001). Fibrotouch diagnostic accuracy of AUC was 0.872, FIB-4 indexdiagnostic accuracy of AUC was 0.765 and the combined diagnostic accuracy of AUC was0.903. There was significant difference between Fibrotouch diagnostic accuracy of AUC and FIB-4 index diagnostic accuracy of AUC(P<0.05), the difference between combined diagnostic accuracy of AUC and FIB-4 index diagnostic accuracy of AUC was significant( P<0.01).The combined diagnostic accuracy of AUC was higher than Fibrotouch diagnostic accuracy of AUC, but no significant difference( P > 0.05) was observed between them.Conclusion: The LSM value and the FIB-4 index were higher in higher Child-Pugh grade patients; LSM value and FIB-4 index were higher in decompensated cirrhosis patients than in compensated patients. LSM values and FIB-4 index were higher in multiple complications patients than in single complication patients. The combined diagnostic accuracy of AUC was higher than other groups. The higher grade of liver function, the greater the LSM value and the FIB-4 index. In different stages of liver cirrhosis, LSM value and FIB-4 value were different, and the decompensation period was significantly higher than that of the compensation period. The LSM value and FIB-4 index of multiple complications were significantly higher than those of single complication. The combination of LSM value and FIB-4 index in predicting the accuracy of AUC in patients with cirrhosis is significantly improved, which is of diagnostic value. It’s valuable to combine Fibrotouch with FIB-4 index in the prediction of liver cirrhosis complications.