| ObjectiveLiver fibrosis is a pathophysiological process is defined by a variety of causes, such as viral hepatitis, alcoholic liver disease, fatty liver, autoimmune diseases caused by the abnormal proliferation of connective tissue of the liver. Any liver damage in the liver healing process in both liver fibrosis process, fibrosis process will be long-term sustainable development into cirrhosis. Therefore, it is important prevention and treatment of liver fibrosis for the treatment of liver disease.Liver fibrosis is the early stages of cirrhosis of the liver, it is reversible at this stage. If you do not timely treated in this period, it is possible to further develop into decompensated cirrhosis, while exhibiting a variety of end-stage liver disease complications. In recent years, TCM liver fibrosis in-depth exploration and research, reported in the literature have shown that many Chinese medicine treatment of liver fibrosis has a unique advantage. How many of these rich data collation mining, summed Chinese medicine treatment of liver fibrosis drug laws, become a serious problem.Data mining is in the wealth of data quickly screened out useful information to get knowledge of them. Under the guidance of experts, data mining, data mining can be achieved on large amounts of data search and analysis functions, and the data summarized adapt the development of things, you can predict the future trend of development. This method has been widely applied in the field of medicine, the technology can speed up the construction of medical knowledge system to improve speed of updating their knowledge, and to lay a good foundation for the development of modern Chinese medicine technology.Methods:Through data mining methods, a comprehensive collection of nearly two decades of Chinese Journal Database includes all the traditional Chinese medicine diagnosis and treatment of liver fibrosis clinical research literature 142, summarize the literature TCM etiology of liver fibrosis, pathogenesis, diagnosis and treatment of traditional Chinese medicine and liver fibrosis efficacy and mechanisms, and in accordance with relevant principles of discipline, medical treatment of drug laws in the quality assessment of liver fibrosis. Identify the most common prescription drugs and syndromes and the highest level recommended medicine. Provide the basis for clinical use of Chinese medicine treatment of various liver diseases, further proposed study existing problems and future research directions.Results:Through research, we obtained the following results:1. liver fibrosis should be classified as Chinese medicine, "accumulate" or "product certificate" range.2. The causes of liver fibrosis was inadequate body upright, heat immunotoxin invasion, blood stasis, showing the virtual real, actual situation coexist. Late liver qi stagnation, liver mass spleen and liver and kidney yin.3. Chinese medicine liver fibrosis of the mechanism that effectively inhibited the collagen network of fibrous connective tissue proliferation, deposition; expressing Ⅰ, Ⅲ,Ⅳ collagen and laminin play an inhibitory effect; absorbent fibers dissolve already formed4. treatment fractions diagnosis and treatment of liver fibrosis, compound treatment, single herb and single treatment and in combination therapy. Commonly used therapies detoxification, blood circulation, Endometriosis, dampness meridians, liver and spleen, liver and kidney and other tune. We should attack supplementation and blood circulation, righting (BNI or liver and kidney tonic) Guben.5. Treatment of liver fibrosis Document statistics 142 met the inclusion criteria of traditional Chinese medicine are:(1) Statistics syndrome: specific types of syndromes often witness type 11 species, wherein each node congestion syndrome, liver spleen deficiency, heat stagnation syndrome, liver and kidney syndrome and liver syndrome occurs most frequently (respectively 26.54%,21.54%,14.04%,12.88% and 8.27%), could be classified as Chinese medicine treatment of liver fibrosis syndrome type standards. (2) Analysis of Prescription:A collection of 86 kinds of prescription, up to 1683 times the frequency, based on the effectiveness of statistics showed:blood circulation agent, replenishing agent, qi agents, settlement agents, expectorants the most frequent (respectively 26.2%,19.2%,134%,9.8% and 7.5%); according to the frequency of prescriptions, recommended choice for all types of parties in the order of:each node congestion syndrome-Xuefuzhuyu soup, liver and spleen Syndrome-Sini, hot and humid stagnation Syndrome YCHT, liver and kidney syndrome-Liu Wei Di Huang Wan and liver qi stagnationXiaochaihutang card.(3) the frequency of drug analysis:most frequently appear before the 20 categories of drugs were:Panax notoginseng(105times), shells (105 times), traditional Chinese medicine (106times), Asako Ren (107times), turmeric (110 times), walnuts (114 times), TPG (115times), rhubarb (116), Atractylodes (117times), citrus aurantium (118times), Astragalus (119times) skullcap (120), Angelica (120 views), white peony root (122), Chuan Xiong (123), licorice (124), turtle shell (134), Salvia (137), wormwood (142), bupleurum (156). Therefore, hepatic fibrosis clinical drug application, blood circulation drugs of choice Salvia, Chuanxiong, white peony root, angelica, red peony, peach, turmeric,2937; qi drug of choice Bupleurum, citrus aurantium, turmeric, pock-jen; spleen Qi drugs preferred licorice, astragalus, Atractylodes; clearing heat the drug of choice capillaris, Scutellaria, rhubarb; nourish liver and kidney drugs preferred turtle, habitat, shells. (4) syndrome factors analysis:factors of disease location (10) and pathogenesis factors (13) analysis showed that the liver, kidney, spleen, and blood divided into the main meridians. Disease because of the wind, phlegm, blood stasis, deficiency, blood gas and so on. (5) efficacy analysis:study of 763 cases of patients show,65.88±18.55)% of the patients shown to be effective, (24.12 ± 7.12)% of the patients showed ineffective, Chinese medicine treatment of liver fibrosis have a significant effect. (6) met the inclusion criteria of 25 documents, TCM medication type, Meridian and medicinal drugs law analysis showed ①Meridian concentrated in the stomach, spleen, heart, liver, reached 66.41% cumulative frequency of occurrence. (2) the use of Chinese medicine taste:taste 97 commonly used Chinese medicine in liver fibrosis, flat, warm and cold-based Smell accounted for 96.95% of the cumulative frequency; with acrid, bitter, sweet Smell mainly occupied 80.35% of the cumulative frequency of occurrence. ③ the use of commonly used Chinese medicine:hemostatic, relieving drugs, prescription diarrhea, diuresis Shenshi drugs, blood circulation drugs medicines and tonics 6 of commonly used Chinese medicine for the liver fibrosis, occupying 72.19% of the cumulative frequency.6.6. Carding and research in Chinese medicine treatment of liver fibrosis in literature, medicine and law in medicine for the treatment of liver fibrosis: (1) Cuban:Xuefuzhuyu soup, rhubarb Zhechong pills, Buyanghuanwu soup (2) effective prescription:Fuzhenghuayu capsule (the highest level for the current study antifibrotic drugs), Fufangbiejiarangan sheet Anluohuaxian pill (3) self side:(1) qi and blood circulation category Party:.... A liver and spleen, liver and blood circulation category includes complex power pills, Kangxian soup; B liver and spleen, liver heat stasis class includes particles cool, slow liver mixture; C Shuganjianpi, blood dampness class includes QGHXR; D liver and spleen, blood circulation, detoxification phlegm stasis class includes Rougan particles Shuganhuazhi capsules. (2) Ruanjian Huoxue Huayu: liver capsule No.5. (3) Yiqi Huoxue Huayu:. A Huoxueyiqi, Ruanjian stasis class includes Yiqi Huayu Fang, Qi Ruan Gan Tang B. Softening blood, qi dampness class includes Softening Granules, Sancao Hugan capsule and Dan JinSanE. C. qi and yin, blood circulation, relieves congestion to product category includes Qileng soup. D. hepatic veins soft mixture. E. Qingganlishi, qi and yin, blood circulation, Endometriosis class includes Bawei Hugan Ganluoxin liver pills. (4) Kidney Yangyin class party A. ney liver, Endometriosis class Rougan square, complex liver slices, soft and liver One Danqi Kangxian soup B. nourish liver and kidney, heat untie the knot categories include kidney detoxification compound Muji granules C. Fang and kidney yang, detoxification dampness, liver and blood, spleen and stomach temperature class II parties including hepatitis and liver fibrosis One party. D. Warming kidney, Liver gallbladder, appetizers soothe the nerves, liver and spleen qi class pills. E. Invigorating Qingrejiedu dampness, spleen and liver include hepatitis B class Thai capsules F. Liver, spleen, kidney, blood circulation, heat and dampness, phlegm detoxification hydrocarbons such as strong Zhuyu Jian.4. A single herb and its components and Bailing Capsule Cordyceps; pulling root vegetables and liver Su granules; silibinin; 2937; oxymatrine and matrine injection; Salvia and Salvia Injection; licorice and Compound glycyrrhizin; litchi nucleus.5. Western medicine combined with adefovir fat joint Fufangdanshen matrine and lamivudine, Xiaochaihutang joint Tiopronin, liver fibrosis prescription combined with lamivudine, Shuang Jia Wu Ling Capsule Combined lamivudine set.Conclusion:Through data mining and literature study method, Chinese medicine treatment of liver fibrosis drug laws were systematically summarized, sorted out syndrome differentiation principles permit use of Chinese medicine for the treatment of liver fibrosis followed the proposed clinical treatment of liver fibrosis Syndrome standard (stasis each node syndrome, liver and spleen syndrome, damp stagnation syndrome, liver and kidney syndrome and liver syndrome), and summarizes the corresponding preferred prescription (Xuefu zhuyu decoction, Sini powder, tarragon decoction, Liu Wei Di Huang pills and Xiaochaihu decoction). While the treatment of liver fibrosis and effective traditional Chinese medicine commonly used to sort and classify description, according to the Cuban side, efficient prescription, single herbs, new medicines, and other categories of self side and introduced a series of selective evaluation. On this basis, elected popular single herbs such as Cordyceps sinensis, pulling root vegetables, silibinin, Panax, licorice, ancient and modern effect as prescription Xuefuzhuyu decoction, rhubarb Zhechong pills, Buyanghuanwu decoction, et al., and filter out and highlights the current three antifibrotic medicine is Fuzhenghuayu capsule, Fufangbiejiarangan sheet Anluohuaxian pill, Within the scope of clinical research, fibrosis is the preferred medicine Fuzhenghuayu capsules. |
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