The Adiponectin Polymorphisms And Risk Of Non-alcoholic Fatty Liver Disease In Chinese Population:A Meta-analysis

Partâ… The adiponectin rs2241766polymorphisms and risk of non-alcoholic fatty liver disease in Chinese population:a meta-analysisBackground:In recent years, the incidence of non-alcoholic fatty liver disease (NAFLD) is rising rapidly worldwide. Non-alcoholic fatty liver disease is the most common choronic liver disease in the world today. There have been several parallels of research to establish the functional variants of some candidate genes and the risk of NAFLD. The adiponectin polymorphism has been implicated in susceptibility to NAFLD in Chinese population, but the results remain inconclusive.Objective:The results of the adiponectin rs2241766polymorphisms and non-alcoholic fatty liver disease risk remain inconclusive. The aim of this meta-analysis is to evaluate the association between adiponectin rs2241766polymorphisms and NAFLD risk.Methods:All eligible case-control studies published up to January2015were identified by searching PubMed, Embase, CNKI, VIP, and WANFANG. A meta-analysis was performed by using the statistical software RevMan5.3and Stata12.0on the basis of strict quality evaluatin on case-control studies.Results:A total of6case-control studies were included. There were897cases and1156controls for rs2241766polymorphism. The result showed no statistically difference in all genotype distribution between non-alcoholic fatty liver disease cases and controls:GG vs. TT(OR=1.38,95%CI (0.95,2.00), P=0.09), TG vs. TT (OR=0.97,95%CI(0.73,1.30), P=0.86), dominant model (OR=1.07,95%CI (0.89, 1.28), P=0.47), recessive model (OR=1.39,95%CI (0.97,2.00), P=0.07), allelic model (OR=1.08,95%CI (0.94,1.25), P=0.27)).Conclusion:This result of meta-analysis suggests that adiponectin rs2241766polymorphism may not be a risk factor of NAFLD in Chinese population. Due to the limited quantity of the included studies, further studies are needed to validate the above conclusion. Part â…¡The adiponectin rs1501299polymorphisms and risk of non-alcoholic fatty liver disease in Chinese population:a meta-analysisBackground:In recent years, the incidence of non-alcoholic fatty liver disease (NAFLD) is rising rapidly worldwide. Non-alcoholic fatty liver disease is the most common choronic liver disease in the world today. There have been several parallels of research to establish the functional variants of some candidate genes and the risk of NAFLD. The adiponectin polymorphism has been implicated in susceptibility to NAFLD in Chinese population, but the results remain inconclusive.Objective:The results of the adiponectin rs1501299polymorphisms and non-alcoholic fatty liver disease risk remain inconclusive. The aim of this meta-analysis is to evaluate the association between adiponectin rs1501299polymorphisms and NAFLD risk.Methods:All eligible case-control studies published up to January2015were identified by searching PubMed, Embase, CNKI, VIP, and WANFANG. A meta-analysis was performed by using the statistical software RevMan5.3and Stata12.0on the basis of strict quality evaluatin on case-control studies.Results:A total of4case-control studies were included. There were605cases and711controls for rs1501299polymorphism. The result showed a significant decreased risk between non-alcoholic fatty liver disease cases and controls:TT vs. GG (OR=0.58,95%CI(0.39,0.87), P=0.009), GT vs. GG (OR=0.74,95%CI (0.49,1.12), P=0.06), dominant model (OR=0.75,95%CI(0.53,1.07), P=0.11), recessive model (OR=0.67,95%CI (0.45,0.99), P=0.04), allelic model (OR=0.73,95%CI (0.55,0.98), P=0.04).Conclusion:This result of meta-analysis suggests that adiponectin rs1501299polymorphism may be a protective factor for NAFLD in Chinese population. Due to the limited quantity of the included studies, further studies are needed to validate the above conclusion.