Numerical Simulation Of Structure And Function Correlation For Clinical Application In The Human Nose

Nasal endoscopic surgery started to treat chronic sinusitis patients from1970s. Compared with the traditional Caldwell-lue nasal operation, it has advantage of retaining the basic structure, maintaining sinus ventilation, drainage and other basic physiological function. After years of development, the nasal endoscopic surgery has become the standard approach for the treatment of chronic sinusitis as a minimally invasive surgery, and extends to the anterior skull base and nose eye related field."structural-functional-symptoms" dialectical ideas, promote the development of nasal endoscopic surgery. It has been changed from the simple treatment of sinusitis, infectious disease, abnormal anatomy of the nasal cavity, to a new level of treatment of upper airway of physiological dysfunction, its applications are not limited to the nasal and sinus lesions, surgical intervention has entered the sleep disorders. The representative technique is nasal cavity ventilation expansion techniques. The rational flow of maintaining nasal physiological function depends on the perspective of nasal airflow, from air flow changes to study local and upper respiratory structural adaptation effect, so the role of nasal airflow dynamics study in the development of nasal endoscopic technique is very important in clinical practice. Based on the computational fluid dynamics (CFD) method and numerical simulation method to carry out research on the respiratory system of biomechanical models, and collect clinical observation data to validate the feasibility and results analysis methods, to understand the relationship between the airway structure and function associated with disease. It provides numerical quantification analysis platform for nasal endoscopy development. The main contents include:1. According to the image of multi-slice spiral CT of nasal cavity in healthy volunteers, we collected60samples of3D modeling, numerical simulation, healthy adult nasal airflow characteristics, and the experimental and numerical simulation results and data reported in the literature are compared to analyse the credibility method and feasibility of this results, we summarized the airflow features of the normal distribution inside the nasal cavity, establish healthy adult nasal airflow dynamics characteristic value and the database distribution characteristics of flow field of nasal cavity and establish nasal numerical simulation research foundation.2. Sinusitis and nasal endoscopic surgery is closely related to the ostiomeatal complex (OMC), its clinical importance leads us to study the flow characteristics of the sinus and ostiomeatal complex which is communicated with the maxillary sinus. We selected1case of adult female images of spiral CT data, reconstructed3D model of nasal cavity and maxillary sinus, studied airflow and temperature normal distribution of maxillary sinus by numerical simulation through the virtual operation research along with the increase of the maxillary sinus ostium diameter, air flow and temperature changes. In order to investigate the influence of maxillary sinus diseases in nasal functionand provides a reference for clinical endoscopic surgery.3. Selected1case of clinical data of patients with chronic sinusitis underwent endoscopic sinus operation, drew of preoperative and postoperative CT data, construct numerical model of the nasal cavity and paranasal sinuses, study changes before and after the operation of nasal airflow distribution and flow characteristic value, collecting clinical data to validate the feasibility and results analysis methods, analyse of the relationship between nasal endoscopy operation of the correct structure and nasal mucosa inflammatory benign outcome, providing more evidence for the pathophysiological mechanism of in-depth understanding of nasal endoscopic surgery in treatment of chronic sinusitis.4.3cases were selected, from the light, moderate to severe OSAHS patients who underwent nasal cavity ventilation expansion techniques after preoperative CT scan data, establish nasal pharyngeal cavity numerical model, and study changes of respiratory airflow distribution and flow characteristic value of before and after operation. It shows the expansion of the nasal cavity surgery for nasal ventilation improvement at the same time, for different diseases, the upper airway resistance situation, and characteristics of flow field obtained by numerical simulation value can reflect the improvement in OSAHS symptoms after operation, collect clinical data to verify the feasibility and results of analysis methods. Provide a theoretical basis to carry out the appropriate expansion of the nasal cavity surgery and research method to personalized nasal surgery expansion.