Clinical Study Of The Zishen Yangmo Decoction On Intrauterine Adhesion Adhesions Lining Repair And Pregnancy Outcome

Objective:To investigate the clinical effects of TCM on intrauterine adhesions by observing the influence of Zishen Yangmo decoction combined with hysteroscopy technology on lining repair and pregnancy outcomes of patients with intrauterine adhesions.Methods:Clinical medical records of100patients with intrauterine adhesions from obstetrics and gynecology outpatient service in professor You zhaoling’s studio of department of gynaecology and the first hospital of changsha was collected and observed, randomly divided into two groups,50cases in control group were treated with hysteroscopy technology and western medicine (female progestogen sequential therapy),2mg pentanoic acid estradiol was taken orally the second day after hysteroscopic surgery,2times/day, for21days,100mg progestin capsule were added in the last5days, once a day.50cases in experimental group were given with Zishen Yangmo decoction on the basis of the control group,1dose/day,400ml decoction,2times/day, the decoction was taken orally the second day after operation,1period of treatment contained continuous treatment for21days. The next period of treatment for2groups both began from the5th day of menstruation, For3consecutive periods of treatment. Curative effect of two groups was observed, the recovery of menstrual quantity, the improvement of TCM symptoms and effects on the lining of the uterus, the levels of serum FSH, LH and E2were detected with ria method; improvement of adhesion and pregnancy outcomes after treatment were observed under hysteroscopy. Result:1. Experimental group and control group were compared in age. course of the disease, uterine cavity operation times, abortion times and TCM symptoms before treatment, p>0.05, there was no obvious difference, the result showed homogeneous comparability.2.1) The total effective rate of comprehensive effect was88%in experimental group after treatment, which was higher than that of control group (84%), the differences between two groups were analyzed by Radit, P>0.05, there was no obvious difference.2) The clinical symptoms improved obviously in two groups after treatment, there was obvious difference, with obvious significance(P<0.05).3) Experimental group showed better than control group in aspects of improving premenstrual breast bilges, fatigue, insomnia, forgetfulness of god and sallow or dull complexion after comparing the changes of main symptoms in two groups after treatment, there was obvious difference(P＜0.05), no obvious difference in the other symptoms, signs, etc.(P>0.05).4) The curative effects showed negatively correlation with the course of disease after comparing the effects of two groups after treatment(P<0.05), for moderate and severe serious patients, experimental group showed better, but there was no obvious significance(P>0.05).5) The curative effect showed negatively correlation with abortion times after comparing the relationship between abortion times and curative effect in2groups(P<0.05). the effectiveness of treatment in experimental was better than that of control group. The difference of curative effects between2groups showed no obvious significance when abortion times was0-2(P>0.05), but showed obvious significance when abortion times was equal to or greater than3(P<0.05).6) Menstruation situation after treatment in2groups:the cycle, period, quantity, color and quality of menstruation were obviously improved.7)The changes of comparison in E2, FSH and LH in maternal peripheral blood is not obvious between2groups before and after treatment, there was no obvious difference (P>0.05).8) The thickness of endometrial after treatment was thicker than that before by comparing the two, there was no obvious difference(P<0.05), the degree of thickening in experimental group was more than that in control group, but there was no obvious difference(P>0.05).9) In terms of pregnancy outcomes, the comparison of clinical pregnancy rate between2groups showed obvious difference(P<0.05), the comparison abortion rates showed no statistical significance(P>0.05).Conclusion:1. Zishen Yangmo decoction combined with hysteroscopy technology and western medicine treatment have good effects on lining repair of patients with intrauterine adhesions, clinical curative effect is exactly, can obviously increase the patient’s menstrual quantity and improve TCM clinical symptoms, the curative effect is better than that of hysteroscopy technology and single female progestogen sequential therapy.2. Zishen Yangmo decoction can increase the endometrial thickness of patients with intrauterine adhesions in experimental group, improve clinical pregnancy rate, pregnancy outcomes needs a long time to observe.