The Relationship Between Atrial Neural Hyperactivity And Atrial Fibrillation Inducibility:Evidences By Neural Recordings

Objective:To investigate the relationship between atrial neural hyperactivity and atrial fibrillation inducibility.Methods:Multi-electrode catheters were attached to atria, atrial appendages and all pulmonary veins. Electrical stimulation at the anterior right and superior left ganglionated plexi (ARGP, SLGP) was used to simulate a hyperactive state of the atrial neural system. Effective refractory period (ERP) and window of vulnerability (WOV) for AF were determined at baseline and during ARGP+SLGP stimulation. Neural activity was recorded from the ARGP.Results:Atrial neural hyperactive state induced shortening of ERP, increase of ERP dispersion and increase of AF inducibility (WOV) at all sites, the mean values of ERP shortening and WOV widening were much more evident at pulmonary vein sties. Compared to the pulmonary vein sites, atrial neural hyperactivity had better linear correlation with electrophysiological changes at pulmonary vein sites.Conclutions:Atrial neural hyperactivity induced more greater electrophysiological changes at pulmonary vein sites and atrial neural activity changes had better linear correlation with electrophysiological changes at pulmonary vein sites.