| ObjectiveIn the prospective study method, through the education to cough syndrome patients’ general information, history, the analysis and research of the four diagnostic information, quality of life, etc, using the method of factor analysis and multiple linear regression analysis, summary of patient-centered cough syndrome evidence rule, provides the valuable reference for clinical work, in order to further explore the pathogenic wind-induced cough syndrome and the objectivity of syndrome differentiation.Methods1.Selection of china-japan friendship hospital in April 2014 to December 2014 hospitalized patients in pathogenic wind-induced cough syndrome diagnosis of 448 patients with chronic cough as the research object.2.Reference to the related standard, determine the clinical manifestations are as follows:cough or choking cough, paroxysmal cough, dry cough without phlegm or less phlegm, throat itching, itching or cough, c have a paroxysmal cough or spasmodic cough, wheeze, not change in the world and the cold wind, lampblack and peculiar smell factors such as sudden or aggravating, cough seriously at night, formed a repetitive seizures, dry cough without phlegm or less sputum, thin white coating on the tongue, pulse float, or tight, or string.Primary symptom, cough, paroxysmal cough or choke to cough, throat itching, in the outside world was not change, the cold wind, lampblack and peculiar smell cough induced by sudden or aggravating factors such as stimulation.A disease:(1) a dry cough without sputum or less;(2) recurrent cough;(3) cough seriously at night. Tongue:thin white coating on the tongue;Pulse condition:pulse float, or tight, or string.With primary symptom and disease in two, at the same time reference above, tongue and pulse condition can be diagnosed with the pathogenic wind-induced cough syndrome.3.using SPSS17.0 statistical software for statistical analysis, general information statistics using frequency statistics, factorial analysis using the method of factor analysis and multiple linear regression analysis.Results1. general information:this study selected in 2014.4-2014.12 months visits China-Japan friendship hospital patients, a total of 448 cases,160 patients with male, female patients with 288 cases, male to female ratio of 1:1.8.Minimum age 19, the biggest 75 years old, average age (47.32±14.19).Progression from 8 weeks to 40 years, average duration (38.58 ± 87.37) months.2. Many factors of clinical characteristic:induced cough feeling is given priority to,57.1% of the patients can cause the cough, buoyed by the smell on the second cause of smoking, lampblack, catch a cold, the cold air.3. Leicester cough quality of life questionnaire (LCQ):cough on the patient’s physical, psychological and social aspects have had a different effect; The lowest scored 13 (tired), the second question (sputum) and 4 (control cough).4. Used to check and treatment:364 patients had done pulmonary function examination, accounting for 81.3%,264 patients had done chest CT examination, accounting for 58.9%,224 patients had been induced sputum examination, accounting for 50%. Drug treatment:the use of traditional Chinese medicine in patients with most, a total of 276 cases, occupy 61.6%, followed by use of antimicrobial agents in patients with, a total of 264 cases, accounted for 58.9%5.factor analysis:the traditional dialectical method and the factor analysis method unifies, a total of extracted nine factor, respectively is Fl qi deficiency factor, F2:blood stasis resistance factor, F3: spleen-deficiency factor, F4:Qi and Yin deficiency factor, F5: accumulation of pathogenic heat in the lung factor, F6:stagnation of liver-QI with deficiency of the spleen factor, F7:hyperactivity of heart-fire and liver-fire factor, F8:Yin and Yang deficiency factor, F9:lung qi deficiency factor.The multiple linear regression analysis:qi deficiency factor y=-0.851+0.018X2, age of pathogenic wind-induced cough syndrome patients of Fl (qi deficiency); Blood stasis resistance winding factor y=-0.234-0.274X12-0.454X6+0.375X5-0.216X9-0.252X11+0.006X3, drinking history of F2 (blood stasis resistance) type had the greatest influence, followed by smoking history, some cough medicine, Chinese medicine, history of allergies, systolic blood pressure; Spleen-deficiency factor y=1.144-0.245X9-0.040X13-0.209X8, BMI of F3 (virtual) temper the pathogenic wind-induced cough syndrome patients had the greatest influence, followed by allergy, pollution of the environment; Qi and Yin deficiency factor y=0.291+0.328X9-0.009X2-0.295X6+0.031X13-0.008X4, allergy in patients with pathogenic wind-induced cough syndrome F4 (Qi and Yin deficiency of) the greatest influence, followed by drinking history, age, BMI, diastolic blood pressure; Evil heat indicates pulmonary factor y=0.835-0.043X13+0.215X1+0.199X9, BMI of pathogenic wind-induced cough syndrome patients F5 (accumulation of pathogenic heat in the lung) had the greatest influence, followed by gender, history of allergies; stagnation of liver-QI with deficiency of the spleen factor y=-2.294+0.013X3+0.480X8-0.513X9+0.031X13+0.268X7, dust exposure to the pathogenic wind-induced cough syndrome patients F6 the influence of the largest, followed by environmental pollution, allergy history, BMI, systolic blood pressure; Hyperactivity of heart-fire and liver-fire factor y=-0.947+0.021 X4+0.481 X8-0.445X 12+0.440X 11-0.376X 10+0.268X6+0.009X2-0.011X3, diastolic blood pressure in patients with pathogenic wind-induced cough syndrome F7 (hyperactivity of heart-fire and liver-fire) had the greatest influence, followed by environmental pollution, traditional Chinese medicine, cough, systolic blood pressure, antibiotics, age, history of drinking; Yang deficiency factor y=0.516+0.432X11-0.032X13, traditional Chinese medicine in patients with pathogenic wind-induced cough syndrome F8 (Yang deficiency) had the greatest influence, followed by smoking history, antibiotics, age; Lung qi deficiency factor y=-0.188+0.497X1+0.640X5+0.254X10-0.008X2, gender on pathogenic wind-induced cough syndrome patients F9 (lung qi deficiency) had the greatest influence, followed by smoking history, antibiotics, age.6. Spearman correlation analysis:except evil heat obstructing the lung and liver stagnation and spleen deficiency type, Qi deficiency and blood stasis obstructing collaterals, spleen qi deficiency, deficiency of both qi and yin, hyperactivity of heart and liver fire, yin and yang deficiency, lung qi deficiency syndrome type were with the course of disease have obvious positive correlation. The longer the course, the more serious the performance. Conclusions1. pathogenic wind-induced cough syndrome belongs to common disease, frequently-occurring disease, all has come on all ages, in the majority with middle-aged patients.2. from the point of view of pathogenic wind-induced cough and syndrome, the cough is not only in the lung, but also with the liver, heart. spleen, kidney, stomach and other organs closely related.3. Master and the accompanied syndromes:the pathogenic wind beam lung syndrome was the main syndrome, Qi deficiency and blood stasis, deficiency of spleen Qi, deficiency of Qi and Yin, pathogenic heat in the lung, liver stagnation and spleen deficiency, hyperactivity of heart-fire and liver-fire, deficiency of both yin and Yang, deficiency of lung qi for main and the other cards.4. Used to check and treatment:364 patients had lung function, accounted for 81.25%,264 patients had chest CT examination, accounted for 58.93%,224 patients had induced sputum examination, accounting for 50%. Treatment:most patients using traditional Chinese medicine (TCM), a total of 276 cases, accounting for 61.61%, followed by patients with use of antimicrobial agents, a total of 264 cases, accounting for 58.93%.5.Qi deficiency, blood stasis resistance, spleen qi deficiency, qi and Yin deficiency, hyperactivity of heart-fire and liver-fire, Yin and Yang deficiency, pulmonary qi deficiency syndrome has obvious positive correlation with course of the disease.The longer the duration, the more serious. |
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