| Objectives To investigate the distribution of somatization symptoms of primary Sjogren’s syndrome patients and the variation of peripheral NKT cells, secretion of these patients. To explore the regulatory mechanism of peripheral NKT cells in primary Sjogren’s syndrome. Methods Patient-Health-Questionnaire-15 was used to assess the incidence and the distribution of somatization symptoms of patients and health controls. And visual analogue scale was used to assess the life quality of patients. The proportion of peripheral NKT cells and their subtype were evaluated by flow cytometer. α-GalCer was applied to expend the NKT cells in vitro for assessing the proliferate function. The level of IFN-γfrom serum, liquid supernatant and intracellular were evaluated and compared with health controls. Results The distributions of somatization symptoms were similar between patients and health controls, but the incidence of somatization symptoms and the somatization disorder of patient were much higher than that of health controls. Fatigue is the most common symptoms of pSS patients. The proportion of peripheral NKT cells of pSS patients were decreased significantly than that of health controls, especially the CD4+CD8- subtype. After the expending of NKT cells in vitro, the level of IFN-γsecretion was elevated. Conclusions The incidence of somatization symptoms of patients was higher significantly than health controls. The problems of somatization symptoms were more serious in pSS patients. The proportion of peripheral NKT cells was decrease in pSS patients, in contrast, the function of IFN-γ synthesis and secretion were elevated, which would influence the balance of Th1/Th2 cells. |
