The Effect And Its Mechanism Of Aerobic And Resistant Exercise On Pre-diabetes’ Glucose Regulation

Objective. We compare the effect and its mechanism of aerobic and resistant exercise with the same exercise time, frequency and intensity on IGR’s glucose regulation, in order to provide a practice principle of controlling and reversing IGR’s abnormal glucose regulation for diabetes prevention by give them a personal exercise prescription.Methods. Randomized Controlled Trial (RCT). We divide the IGR objects who reach our demands into 3 groups randomly, aerobic, resistant and control groups. And compare the changes after 12 weeks’exercise intervention and health education.Results.1. In this research, there is 81.4% IGR whose waist are abnormal (average 88.55-89.13cm), and their percentage of overweight and obesity is 55.7%(average BMI is 24.49-25.06 kg/m2). Personal HOMA2-IR are all>1 with 90.0% IFG’s HOMA2-β decline,82.9% IGT’s HOMA2-β normal. The average value of IL-6 and COR in the 3 group are all exceed the normal value.2. FPG and OGTT 2hPG decline significantly before/after exercise both in aerobic and resistant groups compare with control group. The percentage of IGR, whose blood glucose turn to normal, is significant in aerobic group comparing with control group. The percentage of IGR, whose GSP decline with a large standard deviation, is also significant in resistant group comparing with control group.3. BMI and Waist Circumference decrease significantly in aerobic group compare with control group, and its BMI has positive relationship with its FPG. FINS and HOMA2-IR also decrease significantly before/after exercise both in aerobic and resistant groups compare with control group, but in resistant group, especially in IGT, there is a bigger descending amplitude. However, HOMA2-β, body composition, FFA, LEP, ADP, CRP, TNF-α, IL-6, COR, FGF-21 and GLP-1 has no significant difference between groups.Conclusion.1. In our research, the situation of obesity is not apparent, but they all have IR, IL-6 and COR increased too.2. Both resistant and aerobic exercise can lower blood glucose significantly, and it can be seen that different percentage of IGR turn to normal in different groups. However, there is little change on GSP in both groups, but a large individual difference and more IGR decrease on GSP in resistant group. 3. Aerobic exercise can reduce IGR’s BMI and waist and then lower there FPG. Both aerobic and resistant exercise can lower there HOMA-IR significantly, and the effect of resistant exercise are more apparent than aerobic exercise. But both resistant and aerobic exercise have no influence on HOMA-β, body composition, FFA, LEP, ADP, CRP, TNF-α, IL-6, COR, FGF-21 and GLP-1. So, it is likely that exercise, especially resistant exercise, improve IGR’s glucose regulation and IR through some mechanisms but have few relationship with obesity and cytokines related to obesity.