| Objectives:The research was aimed to explore the academic origins of Prof. Wei Beihai’s spleen-stomach theory, summarize and inherit academic thought and clinical experience of spleen-stomach theory, explore the way of learning, inheritance, and research on famous veteran TCM doctors’academic thinking and clinical experience, improve academic standards and professional skills, enrich and develop academic thinking and clinical use of the spleen-stomach theory, and lay a good foundation for better inheritance and research on famous veteran TCM doctors’academic thinking.Methods:1. Sever and learn the supervisor’s clinical diagnosis, carefully observe the four diagnostic methods, take serious notes, analyze the medication experience and thinking of syndrome differentiation, and explore clinical medication laws.2. Carefully read and summarize supervisor’s articles or published papers, humbly inquiry, combining with clinical experience, seriously write the learning thinking, and summarize up the supervisor’s academic thinking.3. Read the ancient Chinese medicine materials listed by the supervisor, and explore the origins of academic thought to have a better understanding about the academic thinking.4. Use the supervisor’s clinical experience and academic thinking in clinic to summarize and verify the learning outcomes in practice.Contents:1. Research on Prof. Wei Beihai’s academic thinking on spleen-stomach theory and related academic genre’s academic thoughtBy studying the ancient physicians’ important academic works, research shows that the spleen-stomach theory is an important composition of traditional Chinese medicine, and spleen-stomach is also a well-known genre in TCM development process, of which the formation and development process were inseparable with TCM. valued by physicians among dynasties. While in the process of formation and development of this theory, the existing earliest classics in TCM, the "Huangdis Internal Classic", laid the theoretical foundation.’Treatise on Cold Damage Diseases", written by Zhang Zhongjing in Han Dynasty, pioneered the syndrome differentiation and created the clinical foundation. And physicians during the Tang, Song, Jin and Yuan dynasties, especially the four famous physicians in Jinyuan dynasties, enriched and developed the spleen-stomach theory, promote its comprehensive development. In particular the "Treatise on the Spleen and Stomach", written by Li Dongyuan, developed "Huangdi s Internal Classic" academic thinking, and created a unique theory based on previous experience and theory. And in Ming and Qing Dynasties, the spleen-stomach theory got further strengthened and improved, and gradually formed a complete theoretical system which had a significant impact on clinic.Contemporary physicians developed their own characteristics from different angles on the basis of inherited academic thinking, so that the theory was more widely used in clinical. This paper briefly described the part of contemporary physicians’academic thinking and clinical characteristics on spleen-stomach theory.2. Research on Prof. Wei Beihai’s academic thinkingBased on etiology and pathogenesis of the stomach diseases, the complex and diverse clinical manifestations, combined with modern medical research, and flexibility in the use of the method of differentiation of disease and syndrome, the core treatment method,"tonify the spleen-stomach, modify the ascending and descending, regulating the stomach meridian, and descending yin fire " was formed. This article highly summarized four aspects as "tonify the spleen-stomach, modify the ascending and descending, regulating the stomach meridian, and descending yin fire", and in each aspect, the academic origins, thinking, differentiation-treatment laws, and clinical application were described and summarized as the core of this article, which was also a discussion on the way to summary of the research methods on Prof. Wei’s academic thought and clinical experience.3. Research on Prof. Wei Beihai’s clinical experienceThe Prof. Wei’s clinical experience in the treatment of common diseases, including constipation, chronic colitis, headache, stomach-pi syndrome, insomnia, liver disease and peptic ulcer, was summarized and researched. The experience represented main academic thought, and its specific clinical use. In particular, a more comprehensive and detailed treatment of the liver disease clinical experience and specific medication law were summarized.4. Clinical research on Prof. Wei Beihai’s method of "tonify the spleen, regulate the liver, activate the blood circulation and expel the phlegm" as the treatment for non-alcoholic steatohepatitis4.1Objectives:To observe clinical efficacy and use the "tonify the spleen, regulate the liver, activate the blood circulation and expel the phlegm" method (TRAEM) for the treatment of non-alcoholic steatohepatitis, to verify the effect of academic experience inheritance, and to provide practical TCM methods and evidence for non-alcoholic steatohepatitis.4.2Methods:According to the principle of randomized controlled trials, random number table was used, and the patients of non-alcoholic steatohepatitis were randomly divided into treatment and control groups. And based on diet, exercise intervention, the two groups were respectively treated by TRAEM and silibinin capsules for3months. After treatment, liver enzymatic (ALT) and blood lipids (TC, TG) were selected as the main objective items for the diagnosis and efficacy evaluation. And the liver B-ultrasound and Chinese medicine syndrome indicators observation were also taken to evaluate TCM treatment efficacy for non-alcoholic steatohepatitis.4.3ResultsComparing to comprehensive effect of two patient groups, in the treatment group,16cases (35.6%) with obvious effect, and26cases (57.7%) with effect, and the total effective rate was42cases (93.3%). In the control group,9cases (17.8%) with obvious effect, and19cases (42.2%) with effect, and the total effective rate was28cases (62.2%). Comprehensive effects of two groups tested by chi-square test were statistically significant, and the treatment group was significantly better than the control group. After treatment, the serum ALT, AST in two groups had been lowered. Before and after treatment in the treatment group, the differences of ALT and AST were statistically significant (P＜0.01. P＜0.05). and in the control group, the differences of ALT and AST were also statistically significant (P＜0.01, P＜0.05); ALT of the treatment group and control group difference was statistically significant (P＜0.05), indicating that the treatment group and the control group had improved serum ALT, AST, in improving serum ALT treatment group was significantly better than the control group. After treatment, the TC and TG were significantly lowered, and before and after treatment. TC and TG had statistically significant difference (P＜0.01). After treatment. TC, and TG in two groups, differences were statistically significant (P＜0.05; P＜0.01). and the treatment group was significantly lower than the control group. After treatment, the BMI were significantly reduced in two groups, and the BMI differences were statistically significant (P ＜0.05) before and after treatment. After treatment, the symptom pattern scores were significantly reduced in two groups. Before and after treatment, the differences were statistically significant (P＜0.01). After treatment, the symptom pattern scores in two groups were statistically significant (P＜0.01), which showed that the clinical symptoms in both groups had been improved, while the treatment group had a better effect than the control group. After the treatment, the main symptoms as the epigastric fullness, hypochondrium distention, anorexia, lassitude, loose stools and so on in two groups were statistically significant (P＜0.01), which showed that the clinical symptoms in both groups had been improved, while the treatment group had a better effect than the control group.4.4Conclusions:The results above showed that, the TRAEM for non-alcoholic steatohepatitis, could significantly improve the clinical signs and symptoms, especially the epigastric fullness, hypochondrium distention, anorexia, lassitude, loose stools and so on. Also liver function, regulation of blood lipids and reducing the body weight could be significantly improved. Comparing to the modern western medicine, silibinin capsules for non-alcoholic steatohepatitis, the TRAEM had obvious advantages on liver function improvement and blood lipids regulation.ConclusionsThrough three years’learning and researching in-depth on articles and papers of Prof.Wei, the academic thinking and clinical experience were deeply mined and systematic summarized. The core of academic thinking,"tonify the spleen-stomach, modify the ascending and descending, regulating the stomach meridian, and descending yin fire", was proposed, useful exploration was conducted by applying the academic thinking and clinical experience with good effect. So the aim of good inheritance and development was achieved, and clinical skills and academic levels were greatly improved. |
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