| The academic experience of the aged doctors of traditional Chinese medicine is the huge precious wealth of Chinese medicine, only successfully inheriting the clinical experience and the academic thoughts of the aged Chinese medicine doctors can enable the continuous development of the traditional Chinese medicine. As a disciple of Professor Luo Luyi, who is the forth generation instructor of aged Chinese medicine academic experience inheriting project. By follow-up learning and treatments assisting, I always pay attention to experience and understand Professor Luo’s knowledge and the thinking method of recipe, and the main features and principles of clinical medicine usage and addition or subtraction of changes.Professor Luo, as The forth generation instructor of aged Chinese medicine academic experience inheriting project, famous traditional Chinese medicine doctor of Guangdong province, famous doctor of Shenzhen city, has more than40years clinical experience. During this the40years time range, the huge profound attainments of traditional Chinese medicine, rich clinical experience, and expertise in medical difficulty miscellaneous disease, especially for coronary heart disease, viral myocarditis, arrhythmia and so on, were all be obtained by Professor Luo.1. The research and arrangement of Professor Luo Luyi’s academic thoughts and Clinical experienceProfessor Luo Luyi started learning Chinese medicine since his childhood, therefore, he is very familiar with the classic medicine books and numerous famous doctors thinking. Then, he became the disciple of the great masters Li Zhenhua, Zhao Qingli and Zhou Zhongying. after that, according to the "Canon of Medicine" and" Treatise on Exogenous Febrile Disease", the academic thoughts of treatment based on syndrome differention were formed.Professor Luo Luyi’s academic thinking can be summarized as follows, comparing with the classic methods, learning from others, differentiation of symptoms and signs, spleen and kidney, recommending to inspection, treating sputum and blood stasis simultaneously, using insects and strong recipe, ills repeated, acupuncture and medicines, good external governance, health maintenance, and treatment before diseases.Professor Luo Luyi is good at governance of cardiovascular disease clinically, Professor Luo Luyi’s clinical experience can be summarized as follows, Therapy of Tonifying the Kidney and Activating Blood and Dissipating Phlegm on Angina pectoris of coronary heart disease, synfome differentiation of six channels theory on viral myocarditis, warming Yang on chronic arrhythmia, Yang Xin grass soup on Tachyarrhythmia, clearing heat and Activating Blood on venous thrombosis, Strengths of cardiac soup on myocarditis.During the process of learning from Professor Luo, Ilearnt and summarized his clinical experience and academic thoughts, researched the classic theory of chinese medicine, and creatively applied them in clinical practice. The creation areas are showing as follow:inspection theory on Cardiac neurosis, regulating qi-flowing method on Coronary Heart Disease, and external treatment on insomnia, and all of them obtained very good treatment result in clinical practice.2. Clinical Study of Tongmaidixian pills on Angina pectoris of Coronary Heart DiseaseAngina pectoris of coronary heart disease can be the obstruction of chest in chinese medicine. In modern society, the Morbidity and mortality of the arteriosclerosis diseases like Angina pectoris of coronary heart disease has been increasing and become a common disease in today’s society, therefore, the disease’s cause, pathogenesis, and treatment research are always the studying focuses of today’s Chinese medicine researchers.The academic experience of the aged doctors of traditional chinese medicine is the huge precious wealth of chinese medicine. This research is based on Professor Luo’s clinical treatment experience of Angina pectoris of coronary heart disease. Professor Luo Luyi summarizes each of the cause and pathogenesis of coronary heart disease, following the "Golden Chamber" and "yin yang micro strings," the obstruction of chest, locate the mind is the disease area and the present is in the kidney, and the kidney is important for its pathogenesis, phlegm and blood stasis as symptom.In this study, the tonifying the kidney and activating blood and dissipating phlegm methodology is used to treate coronary heart disease, and the changes of clinical efficacy, blood lipids, coagulation and fibrinolysis indicators in carotid atherosclerotic plaque will be summed up to generate clinical experience and discuss the treatment of kidney and blood phlegm and clinical efficacy of coronary heart disease mechanism, further more to carry and broadly apply the aged Chinese medicine doctors’academic thoughts and experiences.ObjectivesIn this study, by observing the Tongmaidixian pills’s affection on the Coronary atherosclerotic heart disease with carotid atherosclerosis in patients with clinical efficacy before and after treatment, affection on Lipids, coagulation and Fibrinolysis, affection on the results of carotid Doppler ultrasound, Including carotid intima-media thickness, carotid plaque type, quantity, kidney and blood phlegm of the efficacy of coronary heart disease, blood lipids, coagulation, fibrinolysis and atherosclerotic plaque, and the intervention of Chinese and Western medicine combined with the unique advantage in the treatment.MethodologyTo select150patients with Combined CHD and cases of carotid atherosclerosis, divide them into3groups randomly, and the three groups can be chinese medicine group, Western medicine group, Chinese medicine combined western medicine group, the three groups of patients were given medicine kidney blood phlegm medicine-Tongmaidixian pills, aspirin and combined medicine atorvastatin calcium and oral treatment with Chinese combined western medicine, give them medicine in24weeks.At the end of the24th week, compare the treatment for three groups of patients with clinical disease score,the impact of clinical efficacy; test patients for total cholesterol, triglycerides, high and low density lipoprotein,6-keto-PGFiα, TXB2, tissue-type plasminogen activator material (t-PA), tissue-type plasminogen activator inhibitor (PAI), NO, carotid artery Doppler ultrasound carotid IMT and carotid artery plaque type, quantity, these results were carried out by comparing before and after treatment group comparative study.With a mean value±standard deviation (X±S), said measurement data were analyzed by t test and variance analysis:comparison between groups using independent samples t-test, before and after treatment group compared with paired sample t test, pairwise comparison between groups using analysis of variance; count data were analyzed by chi-square test:chi-square was used to compare the rate of inspection; Ridit analysis was used to compare ranked data.Result(1) the before and after treatment comparison inside the group, three groups of angina scores were significantly lower (P<0.05or P<0.01), combined with Western medicine group medicine group and symptom scores were significantly lower (P<0.01), while no significant medication group improvement (P>0.05); three groups in angina pectoris, ECG, significant efficiency and efficacy of traditional Chinese medicine symptom total efficiency got improved in varying degrees.(2) the before and after treatment comparison inside group, three groups of TC, TG, LDL-C values were significantly lower, HDL-C values were significantly higher (P<0.05or P<0.01); western group was better than medicine group. Combination group was superior to traditional Chinese medicine and Western medicine group and the group.(3) the before and after treatment comparison inside the group, three groups of NO,6-keto-PGF1α, TXB2, t-PA, PAI were significantly improved (P<0.05or P<0.01); the combination group than the Chinese and Western medicine group and WM group (P<0.01)(4) the before and after treatment comparison inside the group, the three groups significantly reduced the thickness of carotid IMT (P<0.05), the number of carotid plaque was significantly reduced (P<0.01). To reduce artery IMT thickness, traditional Chinese medicine and western medicine group as effective as group (P>0.05), with significantly better than Western medicine group and WM group (P<0.01). Reduce the number of carotid artery plaque, the western medicine group was superior (P<0.01), with significantly better than Western medicine group and WM group (P<0.01).ConclusionThe study result shows that the Tongmaidixian pills patients on angina pectoris, angina symptoms can be improved, especially in the efficacy of traditional Chinese medicine symptoms have a significant effect, and reduces patient TC, TG and LDL-C levels, increased HDL-C levels, lower carotid IMT values; reduce carotid atherosclerotic plaque number. Due to these factors, the kidney phlegm and blood stasis is an important cause of coronary heart disease one of TCM. Inference of body lipids, endothelial function, and regulation of coagulation and f ibrinolysi s may be one of the anti-AS mechanisms of kidney blood phlegm.The Tongmaidixian pills in combination with aspirin and atorvastatin calcium as combined with Chinese and Western treatment of angina pectoris will improve the situation of blood fat, blood lipids, coagulation, fibrinolysis, carotid plaque more obviously. |
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