Related Research Of TCM Syndromes Of Acute Cerebral Infarction And Related Factors In Recent Infection

Objective:①Through the cross-sectional survey of recent infection inpatients with acute cerebral infarction TCM Syndrome, Discussion onrecent infection in acute cerebral infarction TCM syndrome distribution,for the TCM syndrome changes of recent infection of acute cerebralinfarction, provide the basis for the formulation of preventive measures;②In the recent infection disease of acute cerebral infarction,Inflammatory cytokine regulation, pathological changes in bloodcirculation, with cerebral vascular disease period，We assume that theinflammatory reaction formation of recent infection in patients with acutecerebral infarction TCM syndrome also participate in, Investigation ofrelationship between recent infection in patients with acute cerebralinfarction and inflammatory factor and syndrome of traditional Chinesemedicine, To explore the biological basis of recent infection syndromein patients with acute cerebral infarction patterns formed, whichprovided a theoretical foundation for the research of the objectificationof syndrome.Methods:①Theoretical study:Review of research on brain infarction ofmodern medicine and TCM Syndrome Study, And the evolution rules of distribution of TCM Syndromes of apoplexy, And discusses theresearch progress of TCM syndrome of stroke and related factors;②Determination of Western medicine diagnosis standard of acutecerebral infarction, The object of study inclusion and exclusion criteria,Cross-sectional survey method, To determine the object of study for92cases of infection in patients with acute cerebral infarction, In general,phase information and information of four diagnostic methods, data of92patients, By the strict training of professionals, the object of study,mainly syndromes evaluation are unified, the results into the database;③Blood samples were collected for all patients, Each case of fastingvenous blood were extracted by6mlprocoagulant andcollection,immediately delivered Laboratory,Centrifugal separatingserum3000r/min,-80℃preservation， unified examination, allprocesses are strict sterile manipulation, Using enzyme-linkedimmunosorbent assay (ELISA) for detection of serum antibodysandwich method IL-1β、TGF-β、slCAM-l、sEPCR、MMP-9, All theoperation requirements according to the instructions, The collected datais collected into the database. Statistical analysis using SPSS13.0statistical analysis software for calculation, Measurement data bydifferent groups for statistical description use x±s, The differencebetween the group use t test. P<0.05,That difference was significant,Count data using frequency tables (ratio) of statistical description, By using the method of correlation analysis of the correlation betweeninflammatory factors and syndrome elementsResults:①92subjects in general Qi, phlegm syndrome, heatsyndrome had the highest frequency, Through the analysis, combinedwith the syndrome factors of infection ratio in patients with acutecerebral infarction in the near future(Qi deficiency, phlegm fire45.7%,53.3%，42.4%),Visible, recent infection in patients with acute cerebralinfarction and the main symptoms were Qi-deficiency, phlegmsyndrome, heat syndrome;②The research object of performance for asingle syndrome and two cards and the highest proportion, respectivelyis42.4%,35.9%，A certificate of the patients, the "Qi","phlegm" and"hot" type is the most, accounting for33.3%,28.2%,25.6%respectively，Two cards and see, most in the "phlegm+Qi",42.4%, Thesecond is "hot+Qi" and "air+hot" type, accounted for18.2%,12.1%.③Inflammatory factors of IL-1β content in fire syndrome wassignificantly higher than that of non-heat syndromes, testing by tP<0.05，The difference was significant. And the IL-1β content in the Qideficiency syndrome group was significantly higher than that in non-qideficiency syndrome group，testing by t P<0.05，The difference wassignificant. Results of correlation analysis：Fire syndrome, Qi deficiencysyndrome associated with the level of IL-1β, P<0.01, there was statistical significance.④Inflammatory factors of TGF-β were higherthan that of non-phlegm syndrome in phlegm syndrome，testing by tP<0.05，The difference was significant. Results of correlation analysis：Phlegm syndrome associated with the levels of TGF-β, P<0.01，Negative correlation between blood stasis syndrome and the level ofTGF-β, P<0.01had statistical significanc⑤Inflammatory factors andsICAM-1content in blood stasis syndrome was significantly higher thanthat of non blood stasis syndrome，By t P<0.05, the difference wassignificant，The content of sICAM-1is higher than that of non-phlegmsyndrome，Testing by t P<0.05, the difference was significant，Resultsof correlation analysis：Syndrome of blood stasis, phlegm syndromeand the level of sICAM-1positive correlation, P<0.01, there wasstatistical significance。⑥Inflammatory factors MMP-9, sEPCR contentin the blood were significantly higher than that of blood stasissyndrome，Testing by t P<0.05, the difference was significant，Resultsof correlation analysis：Positive correlation with MMP-9, sEPCR levelsin blood stasis syndrome P<0.01, there was statistical significance.Conclusion:①The recent infection in patients with acute cerebralinfarction with Qi deficiency, phlegm, fire as the main symptoms,combination of syndrome elements of more complex， Moreperformance for the separate Qi, phlegm, fire or some type of syndrome combination；②Recent interleukin infection of acute cerebral infarctionin patients with (IL-lβ) there were significant correlations between thecontent changes and fire syndrome, Qi deficiency, may become one ofthe indexes for judging the fire syndrome, Qi deficiency syndrome;③Recent infection of acute cerebral infarction in patients withtransforming growth factorβ (TGF-β) were correlated with the changesof the content of phlegm syndro，Associated with blood stasis syndromenegative, may become one of the indexes for judging the phlegm andblood stasis.④The soluble cell adhesion infection in acute cerebralinfarction in patients with factor-1(sICAM-1) were significantlycorrelated with the content changes of blood stasis, phlegm, could beone of the index of blood stasis, phlegm syndrome⑤Recent infection ofacute cerebral infarction patients with blood compatibility of cell proteinC (sEPCR), matrix metalloproteinase9(MMP-9) content changes had asignificantcorrelation with blood stasis syndrome, blood stasis may beone of the index determination.