| Objective: To explore the related factors affecting the prognosis of patients with acute cerebral infarction(ACI)in different age groups,and to provide clinical reference for the prevention and treatment of patients with acute cerebral infarction in different age groups.Methods: We selected 538 patients with cerebral infarction who were diagnosed and treated in the First Affiliated Hospital of Hainan Medical College from January 1,2019 to December 31.11 patients with incomplete data and 121 patients were lost to follow-up were excluded.Finally,406 patients were included in this study.The clinical data of patients were collected,including gender,age,treatment time,length of hospital stay,smoking,drinking,previous basic diseases,and so on.The subjects were divided into groups: 1.According to the World Health Organization’s age classification criteria,they were divided into youth group(18-44 years old),middle-aged group(45-59 years old),elderly group(> 60 years old);2.The life ability of the patients was evaluated by modified Rankin score(MRS)after 1 year follow-up.The patients were divided into two groups: good prognosis group(0-2)and poor prognosis group(3-6).Spss21.0 analysis software was used for statistical analysis,the measurement data were in line with normal distribution,and the homogeneity of variance was(x)± s)The number of cases and percentage(%)of classified data were expressed.The measurement data were compared between the two groups and analyzed by independent sample t-test;The F-test of variance was used for comparison between groups,and LSD-t method was used for comparison between groups.Chi square test or Fisher’s exact test was used to compare the count data between groups.Multivariate logistic regression model was used to analyze the correlation.The dependent variables were significant indexes evaluated by univariate analysis.The results were expressed by adjusted odds ratio(or)and corresponding 95% confidence interval(CI).The related factors influencing the prognosis of acute cerebral infarction in different age groups after one year were obtained,and the P < 0.05 was statistically significant.Results: Among the 406 patients with acute cerebral infarction,357(87.9%)had good prognosis,including 255(71.4%)males,102(28.6%)females,and 49(12.1%)had poor prognosis,including 26(53.1%)males and 23(46.9%)females.1.Compared with the group with good prognosis,the female ratio,NIHSS score,admission time,hypertension history,cerebral infarction history,AF history,smoking history,drinking history,LAA ratio,the rate of irregular second-class preventive drugs,the ratio of recurrent acute vascular events and age were significantly higher than those in the group with good prognosis(P < 0.05).The results of multivariate logistic regression analysis showed that gender,NIHSS score,and Admission time,smoking history,drinking history,secondary preventive drugs and recurrent acute vascular events were all independent factors influencing prognosis(P < 0.05).2.There were statistical differences in prognosis between the young,middle-aged and the old group(2 = 8.321,P = 0.016),and the prognosis of the young and middle-aged groups was better than that of the old group.3.The results of the analysis of the prognosis related factors in the youth group showed that the difference between NIHSS score and smoking history rate was statistically significant(P < 0.05),and the smoking history rate and NIHSS score of the poor prognosis group were significantly higher than those in the good prognosis group.4.The results of the analysis of prognosis related factors in the middle-aged group showed that NIHSS score,hypertension history,AF history,smoking history and recurrent acute vascular events were significantly higher than those in the good prognosis group(P < 0.05).The results of multivariate logistic regression analysis showed that NIHSS score and smoking history were independent factors influencing prognosis(P < 0.05).5.The results of the analysis of the prognosis related factors in the elderly group showed that the sex ratio,NIHSS score,admission time,cerebral infarction history,AF history,smoking history,drinking history,TOAST classification,secondary preventive drugs and recurrent acute vascular events were significantly higher than those in the good prognosis group(P The history of drinking,secondary preventive drugs and recurrent acute vascular events were all independent factors influencing prognosis(P < 0.05).Conclusions: 1.Gender,age,NIHSS score,duration of admission,history of hypertension,history of cerebral infarction,history of atrial fibrillation,history of smoking,history of drinking alcohol,regular oral secondary preventive drugs,recurrence of acute vascular events,TOAST classification are the related factors of poor prognosis of acute cerebral infarction;2.The related factors of poor prognosis of acute cerebral infarction in different age groups are different;Gender,length of hospital stay,history of drinking,history of cerebral infarction,TOAST classification,regular oral secondary prophylaxis mainly affect the prognosis of elderly patients with ACI;The history of atrial fibrillation and recurrent acute vascular events mainly affect the prognosis of middle-aged and elderly patients with ACI. |
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