| Children with adenoid hypertrophy (CAH) is a common disease in pediatrics. Recurrence of the disease on a long-term basis will easily affect children’s growth and development, intellectual development, and may even induce the occurrence of early pathological change of the cardiovascular system. It will concurrently lead to many complications, such as secretory otitis media, chronic nasosinusitis, nasitis, etc. And it may also affect the appearance clinically, resulting in "adenoid face".The thesis will be divided into three parts, namely literature review, clinical experience summary of Professor Xu Rongqian in the treatment of CAH and clinical research of Qingxianfang in the treatment of CAH. In the first part of literature review, it introduces the name of the disease attributed by TCM, etiology and pathogenesis and progress of treatment. Secondly, summary and exploration have also been carried out on the progress of modern medical research on CAH, including immunoregulation, allergic reaction, clinical treatment, etc. Since the complications of CAH are complex, the analysis has also been made to the relationship between CAH and systemic disease to have a general understanding of CAH.The thesis will conclude the clinical experience of Professor Xu Rongqian in the treatment of CAH in the part of clinic research. Moreover, it carries out clinic research in terms of the cur at ive effect of Professor Xu Rongqian’s treatment of Qingxianfang, and explores studies about86cases of children with CAH, including data col lect ion, statistics, result analysis and discussion, etc. The thesis also investigates in-depth the clinical recognization and progress of research of TCM to CAH so as to lay a sound clinical foundation for the development of TCM and new drugs of TCM in the future.1. Literature ReviewAfter conclusion and retrieval of huge amount of literature and data, the thesis clarifies the name of the disease attributed by TCM, etiology and pathogenesis, TCM treatment, and the rules of treatment according to syndrome differentiation. In addition, it carries out in-depth exploration in terms of the clinical research of modern medicine, including the progress of Imnunological study, the research on etiology, the evaluation of airway obstruction, the latest progress of clinical diagnosis and western medicine therapy.2. Conclusion of Clinical Experience of Professor Xu Rongqian in the treatment of CAHObjective:To summarize the clinic experience of Professor Xu Rongqian in the treatment of CAHMethod:To explore and find out the etiology and pathogenesis of TCM, clinical ideas, therapeutic principles and to summarize the clinical experience of three-stage theory in the treatment of CAH.Results:(1) The basic pathogenesis of CAH is "pathogenic heat lingering, stagnation of the circulation of vital energy, blood stasis, stubborn phlegm"; the basic principle of treatment is "heat removal, regulating the f low of vi tal energy and remove obstruct ion toit, blood stasis removal, phlegm removal, stasis removal".(2) The initiation of the three-stage treatment:Professor Xu Rongqian puts forward the notion that CAH is heat stagnation syndrome in the early stage, the treatment of which should be mainly focus on dispelling wind and heat and reducing phlegm and resolving masses; it turns into syndrome of intermingled phlegm and blood stasis in the middle stage, the treatment of which should be focus on activating blood and eliminating stasis and reducing phlegm and resolving masses, using Qingxianf ang to achieve the appropr iate curat ive effect. In the late stage, it turns into syndrome of yin deficiency of lung and kidney, the treatment of which should be focus on nourishing the lung and replenishing vital essence and tonifying the Bone marrow, using Liuweidihuang pills to achieve the appropriate curative effect.3. Clinical Research of Qingxianfang in the Treatment of CAHObjective:To observe the clinical therapeutic effect of Qingxianfang in the treatment of CAHMethod:86cases of children with syndrome of intermingled phlegm and blood stasis who meet the criteria requirement are brought into the research, including44cases in treatment group and42cases in the control group. They are treated respectively with Qingxianfang and fushuliang nasal spray for3courses. Observation and analysis should be made in terms of the gender and age of children, courses of disease and clinical symptoms, etc. Then conclusions will be made to the clinical symptoms pre and post treatment, integral of syndrome of TCM, qual i ty of life (OSA-18), and curative effect of adenoid volume, the data resulted from which will be processed by SPSSS16.0statistical software.Results:(1) Among86cases of syndrome of intermingled phlegm and blood stasis patients, male patients are67cases (77.91%) and female patients are19cases (22.09%), which demonstrates that males are of higher percentage to catch the disease than females.(2) The patients aged from seven years old to twelve years old account for61cases, taking up70.93%whi le the patients aged from thirteen years old to eighteen years old account for25cases, taking up29.06%, which demonstrates children aged group from seven to twelve years old are of high percentage to catch the disease.(3) The statistics of the adenoid hypertrophy situation among86cases show that hypertrophy of the third degree reaches a relatively high percentage of44.73%, followed by the fifth degree of23.68%. It demonstrates that the hypertrophies of the third and fifth degree are the most common types clinically, accounting for68.42%.(4) The statistical analysis of clinical symptoms among86cases shows that snoring reaches81.39%, buccal respiration reaches76.74%and nasal obstruction reaches72.09%. It demonstrates that snoring, buccal(5) The Improve of clinical symptoms among86cases respiration and nasal obstruction are the three major symptoms clinically. After treatment for1month,P values of two groups are both<0.001for nasal obstruction, with obvious curative effect clinically for two groups. After treatment for3months,P value are<0.05, comparing treatment group with control group, with obvious difference, which demonstrates that the treatment group has more obvious curative effect than the control group after treatment for3months.(6) In the aspect of the adenoid volume in clinical efficacy, there is obvious different between the two groups after treatment in terms of the volume integral with P<0.05. It demonstrates that the treatment group has better curative effect than the control group.(7) The evaluation of quality of life (OSA-18). The comparison of the two groups after treatment,P values are<0.001, with obvious difference. It demonstrations that the treatment group has better curative effect than the control group. |
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