The Research Of Fieber-Depression-Phlegm-Blood Stasis Pathogenesis Theory In Viral Pneumonia By Association Rules

Pneumonia, one of four key diseases prevention in our nation, is common and frequently-occurring for children, of them viral pneumonia accounts for about 1/2. Traditional Chinese Medicine specializes in the treatment of children with viral pneumonia, have a good effect and a large number of clinical studies. Many scholars have conducted many studies with syndrome differentiation and treatment methods, and have had a certain degree of understanding. However, the methods still need objective and normalization. In the situation of Traditional Chinese Medicine Schools emphasis on Chinese traditional research methods combined with evidence-based medicine. There is necessary to deepen the study of infantile pneumonia, using traditional research methods combined with the modern science and technology, make it more objective and normalized.Data mining is an emerging interdisciplinary in the last 20 years, which means the knowledge discovery of databases. Association rule is one of the most common and sophisticated methods in the data mining, it describes the (potential) relationship among data items in the database (attributes, variables), applies to the study on the TCM Syndrome which stress the relations between diagnostics and physical sign.As a national well-known old TCM, my mentor Professor Wang Shouchuan has studied the viral pneumonia for 15 years, treated a large number of the patients, and formed independent academic thought. With the guide of the pathogenesis of heat-constraint-phlegm-blood stasis, he had made good effect and outcome in the treatment of viral pneumonia.In order to lay a solid foundation for the further objective and standard research of the TCM pattern differentiation and treatment for viral pneumonia, study and summarize the experience and academic thinking of the famous veteran doctors of TCM with the modern technology, we will carry out a research of viral pneumonia concerning Heat-Constraint-Phlegm-Blood stasis Pathogenesis theory, using the data mining, mainly the Association rule.ObjectiveThrough the theoretical, clinical and statistical studies, establish the pathogenesis theory of viral pneumonia.Methods To excavate the large sample, multi-center, randomized clinical study of viral pneumonia in the data source, carry out a research of the pathogenesis theory of viral pneumonia with the theoretical, clinical and statistical studies, using association rule, on the basis of literature and theoretical studies.Results1. Theoretical research:Some scattered words about the pathogenesis of pneumonia which is relative with heat, constraint, phlegm and blood stasis in the ancient medical books, by studying the ancient and modern literatures; Some modern scholars put forward treatment with phlegm-heat-constraint block or phlegm-heat-stasis block, and there are some clinical research reports about them; all this shows that the study of Heat-Depression-Phlegm-Blood stasis Pathogenesis theory has ancient and modern basis of expert advices.2. Clinical research and mathematical research:Using the disease data sources from clinical studies, based on clinical studies, start from the clinical Syndrome, compute association rules, it can be found that the pathogenesis of intense heat pathogen, lung qi constraint, phlegm and fluid obstruction and blood vessels stasis obstruction (the "heat, constraint, phlegm and blood stasis") often can be seen in the onset of the occasion.The pathogenesis of overabundance of pathogenic heat is clear in the early and middle stage, slight late, while the pathogenesis of lung qi constraint and phlegm-fluid accumulation are obvious in the whole process, blood stasis obvious in the early and minor late. Pathogenesis Evolution rule of the experimental group and control group is similar in drug intervention, but more for support, most of the time, most of the itemsset (such as heat syndrome, depressive syndrome, sputum or fever syndrome associated with depression syndrome, fever syndrome associated with sputum, fever and depression associated with syndrome of phlegm, etc.) between the two groups was significant (P<0.05-0.01), and compared with the control group 1 to 3 days before disappearing. It shows that the experimental group is better than the control group in the aspects of improving the rising heat pathogen, Qi constraint, hold the spit with the rising dampness or heat evil associated with lung disease resistance machines depression, the rising heat pathogen, hold the spit dampness associated with disease pathogenesis, the rising heat pathogen and lung resistance with depression pathogenesis associated with dampness. In the whole process of disease, heat, constraint, phlegm and blood stasis associated each other and form the 2 to 7 interrelated pathogenesis, such as the formation of hot and constraint, hot and sputum, heat and blood stasis, phlegm and depression, depression and blood stasis, phlegm and blood stasis, heat and constraint and sputum, heat and depression and blood stasis, heat and phlegm and blood stasis, phlegm and blood stasis with depression, heat and depression associated with phlegm and stasis, or heat causing constraint, causing phlegm and causing stasis, or depression causing heat, causing phlegm, resulting in stasis, or phlegm causing depression, causing heat and causing blood stasis, or stasis causing heat, causing constraint and causing phlegm. There is a probability of regularity and strength of interactions in the evolution of the pathogenesis, the changes of the regularity and probability almost stay the same before and after treatment. By thermal or induced sputum or blood, etc. Depression and depression from the heat or phlegm or blood stasis caused by high probability, it is basically little changed before and after treatment. From the phlegm or blood caused by depression or the probability of heat treatment often can be seen daily decline. Stasis caused by the heat or the probability of depression or sputum is often greater than the heat or depression or the probability of stasis caused by phlegm.3. The main content of heat-constraint-phlegm-stasis pathogenesis theory about viral pneumonia:In viral pneumonia, the majority of pathogens from the heat, heat induced Qi constraint, phlegm accumulation due to heat, blood stasis due to qi constraint. Meanwhile, Qi constraint, phlegm accumulation, blood stasis are the factors which make heat pathogen retention. Heat, constrain, phlegm, blood stasis and the coexistence of the four inter-related, progressive gradual, reciprocal causation, ring linked to the disease process is extremely easy in the formation of thermal depression, the pathogenesis of heat-constraint, heat-phlegm, heat-stasis, phlegm-constraint, phlegm-stasis, or heat-constraint-phlegm, heat-constraint-stasis, phlegm-constraint-stasis, or binding of heat-constraint-phlegm-stasis often can be seen in the course of this disease. In this disease, the heat pathogen infestation is the initiating factor of this disease, the struggle between heat pathogen and healthy qi throughout the whole process of the disease, but under the drug intervention, the disease has gradually decreased due to illness changes, so dose the possible influence of the other pathogenesis. The possibilities of various etiology and pathogenesis will influence the pathogenesis variation of lung qi constraint and phlegm-fluid accumulation little change over time, and they are important pathogenesis in this disease and took the domination position. Phlegm and blood stasis are also the product of physical pathology, especially the blood stasis, which influence to the heat and stasis was larger than heat and stasis to them, play an important role in the evolution of pathogenesis.Conclusion1. Heat, constraint, phlegm and blood stasis are the basic pathogenesis of the acute viral pneumonia. This pathogenesis theory of viral pneumonia established through combining the theoretical, clinical and mathematical studies bases on good practice and evidence-based foundation, the establishment of viral pneumonia on the theoretical system of Chinese medicine and traditional Chinese medicine, diagnosis and treatment of objectivity, standardization, standardization of enlightening.2. Study the academic thought of famous veteran doctors of TCM, using the traditional Chinese medicine theory of knowledge and modern research methods (including data mining), with refined pathogenesis pathological differentiation perspective and sum up the role of the law of prescription drugs is beneficial to promoting the heritage and name of the old Chinese academic thought. To mentor Professor Wang Shouchuan treatment of pneumonia, the major toxic form of academic thinking of the thermal depression refining the theory of phlegm and blood stasis disease was acute pneumonia virus basic pathogenesis pathology of TCM broad, innovative viral pneumonia theoretical system of TCM treatment laid a good foundation.3. The TCM experimental group is better than western medicine group in improving the heat, constraint, phlegm, blood stasis and its associated pathogenesis. Application of association rules can create outstanding content of traditional Chinese medicine, more in line with Chinese characteristics and laws of TCM clinical efficacy evaluation.