Clinical And Experimental Research For Preventing Deep Venous Thrombosis Of Lower Extremity With Yang Yin Huo Xue Decoction After Artificial Hip Or Knee Replacement

Deep vein thrombosis (DVT) after total artificial joint replacement is a common complication, which can cause severe lower limb circulatory disturbance or even fatal pulmonary embolism. Its pathogenesis and harm has been extensively concerned and profoundly researched. According to foreign reports, the incidence rate of DVT is about 40% if having not taken any preventive measures after total joint replacement operations. It still lacks a unified and effective way to prevent the formation of DVT currently. The treatment of traditional Chinese medichine to thromboembolic diseases has experienced a long history owning unique skills, precise effects, few side effects, low cost so that it is easily accepted by the majority of patients and its advantages are increasingly obvious.This dissertation systematically analyzes the accumulated knowledge of DVT from ancient Chinese medicine to modern medicine and summarizes the causes and pathogenesis, principle and therapy, various clinical diagnostic and preventive measures. From clinical and experimental studies, it explores the efficacy and mechanism of Yang Yin Huo Xue Decoction preventing the formation of lower limb DVT after joint replacement.Clinical study taking the objects of 60 patients with lower extremity after total joint replacement proves that Yang Yin Huo Xue Decoction can nourish yin and clear away heat, dredge the channel and promote blood circulation. From significantly prolonging prothrombin time and inhibiting platelet aggregation, it can effectively improve the blood hypercoagulable state and prevent thrombosis formation, while little effect on platelet levels, non-induced bleeding tendency, significantly reducing postoperative clinical symptoms. Experimental study taking the objects of 40 rats of DVT model by detecting the levels of indicators related to blood coagulation changes in rats plasma and observing the slices of rat inferior vena cava proves that Yang Yin Huo Xue Decoction can significantly elevate t-PA,6-keto-PGF1αand NO levels, while reducing PAI, TXB2 and ET levels in rat plasma. The decoction has the super capacity of breaking the three elements of Virchow pathology, inhibiting thrombosis effectively, promoting thrombolysis, protecting endothelial cells, repairing vein wall damage, maintaining vascular function.The research results show that the Yang Yin Huo Xue Decoction for preventing DVT has good control effect and it is superior to the low molecular weight heparin on high security. With economic price, convenient taking, favorable compliance, this Chinese medicine prescription is worthy of clinical utilization.