| ObjectTo study the level of adiponectin and the intima-media thickness (IMT) between MHD patients and healthy populations. By measuring adiponectin level of the MHD patients and analyzing the relation among adiponectin and MHD time, gender, primary disease, blood lipids, CRP, albumin, body mass index (BMI), etc, The feasibility of the ADPN being as risk indicators of MHD patients with cardiovascular disease was investigated; By comparing biochemical level, ADPN, ADPN of MHD patients treated by Chinese traditional compound recipe-SanQin Oral Solution (SOS), the treatment mechanism of SOS is studied.Methods60 MHD patients suffering from the diagnostic chronic renal failure and 20 people in healthy control group are studied. The patient is divided into three groups:General dialysis unit, General dialysis group+ traditional Chinese medicine (TCM) group, the healthy control group. Double antibody sandwich enzyme-linked immunosorbent assay (ELISA) is used to measure various group plasma adiponectin levels. GE LOGIQ7 color Doppler ultrasonography is used in determination of the Group of IMT level. Gender, age, weight, blood pressure, body mass index (BMI) and other body parameters are collected. Simultaneously lipids, CRP, serum albumin, creatinine, and other indexes are measured. Finally statistics software is applied to analyze the relationship between adiponectin and these indexes and the change of these indexes after medication.Results1. By One-way ANOVA, it is found no difference is showed among healthy controls and dialysis, dialysis + medication group in age, BMI, gender and no difference is showed in dialysis time between dialysis and dialysis +medication group.2. Alb (P= 0.09), TG(P= 0.867), Chol (P= 1.000) levels of healthy control group, dialysis, dialysis + medication group were not significantly different. By comparing BUN, Scr, CRP, ADPN, IMT of healthy control group, dialysis, dialysis + medication group, the average level of dialysis group is higher than the control group (P<0.05), the average level of dialysis + medication group is higher than the healthy control group (P<0.05), and dialysis, dialysis + medication group showed no significant difference (P> 0.05). comparing Hb, HDL-c of Healthy control group, dialysis, dialysis + medication group the average level of dialysis group is lower than the control group (P<0.05), the average level of dialysis +medication group is lower than the control group (P<0.05), and the Hb between dialysis, dialysis+medication group is not significantly different(P> 0.05). By compariing LDL-c of Healthy control group, dialysis, dialysis+medication groups, the average levels of dialysis +medication group are higher than those in healthy controls (P<0.05), and for LDL-c between dialysis and healthy control group there is no significant difference (P> 0.05), LDL-c of dialysis, dialysis+ medication group is no significantly different (P> 0.05). Those comparing suggests the MHD patients have conditions of lipid metabolism disorder, micro-inflammation and malnutrition, arteriosclerosis.3. Hemodialysis group are divided by IMT levels into carotid athero-sclerosis Group, normal carotid group. carotid atherosclerosis Group are compared with normal carotid group in the levels of all related indexes. Dialysis time, BUN, Scr, Hb, LDL-c are no significant differences;and for BMI, TG Alb, Chol HDL-c, CRP adiponectin there is a significant difference. 4. Hemodialysis group are divided by gender before medication, compared with the male the adiponectin levels of female groups is significantly higher (P<0.05).5. Hemodialysis group are divided by their primary diseaseinto diabetes group and non-diabetic group:the adiponectin levels of non-diabetic group ofis significantly higher(P<0.05).6. Correlation of adiponectin in MHD patient and dialysis time, BUN, Scr, Hb, LDL-c, BMI, Alb, TG,, HDL-c, CRP relationship is simply analyzed: adiponectin negatively correlated with BMI (r=-0.790, P<0.05); adiponectin negatively correlated with TG (r=-0.827, P<0.05); and Chol adiponectin negatively correlated (r=-0.393, P<0.05); adiponectin and Alb are correlation (r= 0.320, P<0.05); adiponectin negatively correlated with LDL-c (r=-0.115, P<0.05); adiponectin negatively correlated with CRP (r=-0.802, P<0.05); fat adiponectin positively correlated with HDL-c (r= 0.693, P<0.05); adiponectin and age, duration of dialysis, BUN, Scr, Hb was no significant correlation.7. Adiponectin being as dependent variables, multiple regression analysis is used to analyze simple related LDL-c,BMI,Alb,TG,HDL-c,CRP. With multiple stepwise regression analysis the results show:(CRP=β-0.582, P< 0.05), (BMI=β-0.281, P< 0.05), (Alb 0= 0.152, P< 0.05) is the blood level of independent factor. The determine coefficients is 0.798, that may explains the total variation is 79.8%. The regression equation is adiponectin= 16.55 4-1.250 CRP-0.645BMI 1.006 Alb.8. Comparison between hemodialysis patients with simple dialysis group and dialysis + medication group:the indexes after the experiment, simple dialysis group and dialysis + medication group in BUN, Scr, Hb, TG, LDL, IMT is no significant differences; HDL and adiponectin of dialysis + medication group is significantly higher than simple dialysis group, CRP significantly low, the two independent samples inspection, is significant differences.Conclusion1. MHD patients have disorders of lipid metabolism, minor inflammation, malnutrition, carotid atherosclerosis. 2. The adiponectin levels of non-diabetic group is significantly higher than diabetic group (p<0.05); The adiponectin levels of female group is significantly higher than male group (p<0.05).3. By multiple regression analysis, CRP, BMI, Alb is the independent factor blood level of adiponectin. The determine coefficients is 0.798, that may explains the total variation is 79.8%. The regression equation is adiponectin= 16.554-1.250 CRP-0.645BMI 1.006 Alb.4. The Chinese Medicine of Sanqi Oral Solution is effective to raise the level of ADPN, but is no effect on the IMT.
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