"heart Summer" Theory And Its Receptor Regulation Mechanism

1 ObjectiveThis study tries to find the meanning of the adaptive regulation of "the heart responding to summer", and explore the impossible methods of empirical study in Visceral Manifestatina Theory research. The study has two parts, the theoretical research makes views of the functional activities of qi, and the experimental study observes the receptors in diovascular system.2 Methods2.1 The Theoretical ResearchThis article using philological method to explore the scientific connotation of "corresponding to nature", card the theoretical structure of the heart zang-organ, put forward the feasibility of studying "the heart responding to summer" theory from the view of the functional activities of qi, and then summarize the hypothesis of "the adaptive regulation of the heart responding to summer".2.2 The Experimental Research2.2.1 Collectivity designPineal gland secretes melatonin to regulate the activity of body organs according to the light signal which accepted by retina; Receptor is very important to the functional regulation of diovascular system, and dicides the result of the functional regulation. So, this study interferes in the secretion of pineal gland, and research the change of receptor's expression in summer and winter.2.2.2 Experiment animalSprague-Dawley male rats, weighted 80-100 gram, were randomly divided into groups as normal, model, false operation, natural light, ate and drank freely, room temperature.The false operation and the operation of removal pineal gland were carried out at 1 month before the Winter Solstice and the Summer Solstice each year, rats were bred after the operation and were decollated at night on the Winter Solstice and the Summer Solstice.2.2.3 Test methodsHeart rate and blood pressure are detected with the BP-98A sphygmomanometer; and the receptors are detected with the method of enzyme linked immunosorbent assay(ELISA).2.2.4 Analysis methodsThis study use SAS8.2 to do statistical analysis.2.2.5 Results:This study finds that the optical signal transduction pathway with pineal land maybe not the sole way to to communicate body and nutrue, and the strength of regulation is diffirent in summer and winter. So, the "the heart responding to summer" theory maybe showed as the strength of regulation.3 Conclusions3.1 Controlling blood circulation is the base of "the heart responding to summer" theory, but we could not understand it as vasomotor directly. The strength of regulation in summer and winter may be the meaning of this theory.3.2 The optical signal transduction pathway with pineal is very important in the adaptive regulation course of "the heart responding to summer", however, it may be not the sole way to to communicate body and nutrue. So, it's necessary to study deeply.