The Value Of Wave Intensity In Left Ventricular Function

Background:Concerning the cardic function of patients, we only examined the heart in the human body directly. However, the heart and the arterial system are not separated and their function are depended on each other.Wave intensity(WI) is a hemodynamic index,which could be used to evaluate the working condition of the heart interacting with the arterial systerm. It can be defined at any site in the circulatory systerm and provides a great deal of information, which includes three parts:accelerating wave intensity (W1),negative area (NA),decelerating wave intensity(W2)Objective:The aim of this study is to obtain the normal values of WI and to explore the relationships of W1 and left ventricular systolic fuction,W2 and left ventricular diastolic fuction in healthy persons.Material and Methods:E/A,LVEF,W,,W2,NA,R-W1, W1-W2were recorded with color Doppler ultrasonography machine(Prosound a 10, ALOKA Company,Tokyo,Japan).152 volunteers were divided into three age groups. E/A, DT,IVRT,AT,PVa-dur,LVEF, W1,W2 and 6minutes walking distance(6MWD) were measured in 81 patiens with CAD, who have more than 50% stenosis in one of coronary arteries at least., Left ventricular+dp/dtmax were measured in 47 patiens with left ventricular catheterization. The patients were devided into three groups according to the level of LVEF and were devided into four groups according to E/A,AT and PVa-dur. the data were analysed with one-way ANOVA and Pearson.Results:1.The normal values of W1 in the normal subjects groups were 10976±7373mmHgms-3,8350±3959 mmHgms-3,8250±3737 mmHgms-3 respectively; W2 were 1803±1054mmHgms-3,1822±946mmHgms-3,1919±863mmHgms-3 respectively.There were no significantly difference in each group(p>0.05).There were a slightly correlations between W1,W2,E/A,NA and the age,but not any correlations between R-W1,W1-W2,LVEF and the age were found.2. W1 decreased significantly with the attenuation of LVEF,6MWD and LV+dp/dtmax. Moreover there was statistical significance in every two groups. W1 has obviously correlations with LVEF,6MWD and LV+dp/dtmax, p< 0.01.3.The value of W2 in patients with impaired diastolic fuction moderately to severiously was obviously smaller than that of the patients whose left ventricular diastolic fuction was normal to slightly impaired. There were weak correlations between W2 and DT (r=0.282,p< 0.05),obvious positive correlations between W2 And E/A,6MWD(r=-0.322,r=0.376, p< 0.01) and no correlations between W2 and IVRT,AT,PVa-dur.Conclusions:The results of this study suggest that there were no statistical significance between every two groups with different age and W1, W2 have weak correlations with age in normal subjects; W1 can be used to evaluate the left ventricular systolic fuction in patients with CAD; W2 may be used to evaluate the left ventricular diastolic fuction in patients with CAD; WI as a new technique may be useful for evaluation of left ventricular function and may have some clinical application in future.