Study On The Influence Factors Of Oriented Efficacy Exertion Of Dihuang (Rhizoma Rehmannia) In Formula

Objective:To study the influence factors of oriented efficacy exertion of Dihuang (Rhizoma Rehmannia) in formula. Clarifying the compatible mechanisms of usual compatible structures between Dihuang and other herbs and summarizing Dihuang's applying law in formula.Methods:1034 pieces of formulae containing Shengdihuang (Raw Rhizoma Rehmannia) and 739 pieces of formula containing Shudihuang (Rhizoma Rehmannia Praeparatae) from The classic format of Formula Dictionary of Traditional Chinese Medicine were collected, and these formulae data bank in Micro-Excel were set up. Then statisticsing and analyzing the effectiveness influence factors of Dihuang including compatibility, dosage, processing, dosage form, usage and provenience place by statistic methods of classification.Results:The leading six kinds of Chinese herb that compounded with Shengdihuang are tonic drugs, heat-clearing drugs, diaphoretic drugs, drugs of activating blood circulation, drugs of eliminating Dampness through diuresis, and hemostyptic drugs. Shengdihuang usually compound with Dangui (Radix Angelicae Sinensis), Baishaoyao (Radix Paeoniae), Ejiao (Colla Corii Asini), Maimendong (Radix Ophiopogonis), Suanzaoren (Semen Zizyphi Spinosi), etc, with usual dose of 5-20g when enducing effect of nourishing Yin and promoing the production of body fluid. When enducing effect of removing heat to cool blood, Shengdihuang usually compound with Chishaoyao (Radix Paeoniae Rubra), Xuanshen (Radix Scrophulariae),Huangqin (Radix scutellariae), Shigao (Gypsum Fibrosum), Mutong (Caulis Akebiae),etc, with usual dose of 5-20g, and usually take medicine with congee, and the fresh is best. When enducing effect of activating blood circulation, Shengdihuang usually compound with Honghua (Flos Carthami), Niuxi (Radix Achyranthis Bidentatae), Dahuang (Radix et Rhizoma Rhei),etc, with usual dose of 3-12g;and it would be better if use the fresh product and take medicine with wine; the medicina broth., pulveres, or vina is usually taked in fresh haemostasis, and pilula is usually taked in long time stagnant blood. When enducing hemostyptic effect, Shengdihuang usually compound with Puhuang (Pollen Typhae), Cebaiye (Cacumen Biotae), Ejiao (Colla Corii Asini), and so on, with usual dose of 5-60g; and it would be better if use the carbo processed product, it is usually taked in medicina broth, raw juice for oral use and pulveres for external use.When enducing the effect of improving acuity of vision, Shengdihuang usually compound with Fangfeng (Radix Ledebourellae), Xixin (Herba Asari), Cheqianzi (Semen Plantaginis), Juhua (Flos Chrysanthemi),etc, with usual dose of 5-20g; and it would be better if take medicine with green tea.The leading six kinds of Chinese herb that compounded with Shudihuang are tonic drugs, heat-clearing drugs, drugs of activating blood circulation, drugs of eliminating Dampness through diuresis,astringent drugs and drugs for dispelling internal cold.When enducing effect of nourishing Yin and blood,Shudihuang usually compound with Dangui (Radix Angelicae Sinensis), Baishaoyao (Radix Paeoniae), Ejiao (Colla Corii Asini), Maimendong (Radix Ophiopogonis), Mudanpi (Cortex Moutan Radicis); Huangbai (Cortex Phellodendri), Zhimu (Rhizoma Anemarrhenae), etc, with usual dose of 5-20g for nourishing the blood, and 15-60g for nourishing Yin, it would be better if take medicine with congee for nourishing the blood, and with salt soup for nourishing Yin. When enducing effect of tonifying didney essence and replenishing marrow,Shudihuang usually compound with Gouqizi (Fructus Lycii), Lurong (Hairy Deerhorn), Shanzhuyu (Fructus Corni), Shanyao (Rhizoma Dioscoreae), etc, with usual dose 15-60g, it would be better if take medicine with salt soup. When enducing effect of nourishing Yin to tonifying Qi, Shudihuang usually compound with Renshen (Radix Ginseng), Huangqi (Radix Astragali seu Hedysari), etc, with usual dose 5-20g, it would be better if take medicine with congee. When enducing effect of nourishing Yin to help Yang, Shudihuang usually compound with Rougui (Cortex Cinnamomi), Zhifuzi (Radix Acontile Praeparatae), etc, with usual dose 15-40g, it would be better if take medicine with wine.Conclusion:Compatibility, dosage, processing, dosage form, usage and provenience place have different influence on efficacy exertion of Dihuang. The compatibility has the key influence on the oriented exertion of Dihuang efficacy. The dosage has the key influence on the efficacy magnitude of Dihuang. Dosage form mainly influent the exertting velocity and persistence time of Dihuang efficacy. Time for taking drugs can influent the effective location of Dihuang,.The material taking medicine and processing method can enhance some efficacy and restrict bias of Dihuang. provenience place influent the efficacy magnitude of Dihuang.