| Recurrent Spontaneous Abortion(RSA)is clinical common and one of the stubborn diseases that the whole world pay attention to.Its'attack rate has reached to 0.4%--0.8%in reproductive aging women.It not only harms their physical and mental health,even causes lots of family problems,which are dangerous to the society.So it has the positive clinical and social meaning of the research on RSA.At present,except the anatomy and immunity aspects, 60%reasons of RSA are unknown.There is no ideal drugs and method in treating RSA at home and abroad.So now it has become common concern hot spot of the medical profession about how to prevent and treat RSA effectively.However Traditional Chinese Medicine(TCM)not only has its unique advantages on preventing and treating RSA,but also has made a good clinical effect.TCM is a great treasure house,ancient and modern literature of TCM about RSA included the valuable diagnosis and treatment experience which is worth to mine.The paper from ancient and modern literature collation and analysis of prescriptions with theoretical study starts,concluded ancient and modern literature research overview,syndromes and treatment regular of prescription of RSA,with a view to provide a clinical useful reference.1 Relevant Literature researched and differentiated of Traditional Chinese Medicine of Recurrent Spontaneous AbortionThe author used TCM documental study of"discriminating thoughts among different academic schools and probing academic origin"combining with textual research and modern analytic method,and gave classified study of all kinds information.The document study in different dynasties showed"Huatai"as the denotation of RSA began from the Qing Dynasty while as the treating means started more than 1000 yeas ago.The reason of RSA lays particular emphasis on the damage of the Cbongren of the mother,the asthenia of Qi and blood,grieved feelingand lots of birth also causeRSA.Thepathogenesis pays more attention to the astheniaof the kidney and spleen.In treating methods, replenishing drugs much used in treating RSA.Taboo medicine also can be used in case of correct diagnosis.In precaution and rehabilitation,spirit nursing, rest in daily life,sexual desire restraining and marriage in appropriated age should also pay attention to.The document study of 20 recent years showed in etiology there were much deep study in not only parent factors such as the abnormality of the reproductive organ,infection factor endocrine factor but also fetal factors, such as the abnormality of the fertilized ovum and the placenta which is worth further studying by scientific technique.And the pathogenesis of deficiency of kidney and spleen is important,blood-stasis,blood-heating should also consider.The principle of paying much attention to precaution and combining precaution and treating is worth thinking highly of for doctors.Although special recipe for special disease need further study,we should advocate differential diagnosis.The prognosis of tocolysis by traditional Chinese Medicine shows the therapeutic effect is safe.Documental study of 20 recent years canbe classified in three sections:theoretical study,clinical study and laboratory study.In etiology of theoretical study,there were significant development in the study of endocrine secretion and immunology.A breakthrough in clinical study should belong to traditional medicine treatment combined with different diagnosis.The most encouraging thing in laboratory study is modern TCM doctors get hand of up-to-date scientific techniques,and enhance studying level of traditional Chinese gynecological theory to molecular level.2 Study on the laws of syndrome differentiation and treatment of prescriptionsThrough analysis of statistical methods for the ancient and modern prescriptions,sum up the using condition and characteristics of these prescriptions treating RSA,to explore the regularity of syndrome differentiation and treatment and removal of the drug group about RSA,for clinical drug reference,and be benefit to the literature research and theoretical improvement on this disease.â… The laws of syndrome differentiation and treatment of ancient prescriptions (â… )Method Ancient prescriptions'choice as A dictionary of Chinese Medicine Prescription for the main research goal,screened up to the Eastern Han Dynasty, down to the end of the Qing Dynasty and republic prescription literature data about the treatment of RSA.Standardize data,establish prescription database, and make analysis of frequency of use,cluster through the use of statistical methods to sum up its syndrome and treatment regularity of prescription.(â…¡)ResultsIn the statistical analysis of prescription of results before the Song dynasty,medication to Chinese Angelica,Szechwan Lovage Rhizome,Largehead Atractylodes Rhizome,Ginseng,Radix Glycyrrhizae;there is the larger proportion to replenishing drugs(34.7%),drugs for warming interior(11.1%), drugs for relieving exterior syndrome(11.1%)and drugs for arresting discharge(9.7%),cumulative frequency up to 66.7%;medication Partial to warm and bland;mainly to sweet taste;the drugs mainly into the liver meridian (16.8%),the kidney meridian(15.9%),the spleen meridian(15.0%);in drug combinations by cluster analysis,to mainly treat the RSA caused by the asthenia of Qi and blood and kidney debilitation.In the statistical analysis of prescription of results during the Songjinyuan Dynasty,medication to Prepared Rehmannia Root,Chinese Angelica, donkey-hide glue,Largehead Atractylodes Rhizome,Ginseng;there is the larger proportion to replenishing drugs(24.0%),drugs for warming interior(10.9%), heat-clearing drugs(9.4%),stasis-eliminating drugs(7.8%),cumulative frequency up to 66.7%.medication Partial to warm and bland;mainly to sweet taste;the drugs mainly into the liver meridian(19.9%),the kidney meridian(15.9%),the spleenmeridian(15.9%);in drug combinations by cluster analysis,to mainly treat the RSA of kidney deficiency and the asthenia of Qi and blood.In the statistical analysis of prescription of results during the Ming and Qing dynasty,medication to Chinese Angelica,Largehead Atractylodes Rhizome,White peony Alba,Szechwan Lovage Rhizome Prepared Rehmannia Root; there is the larger proportion to replenishing drugs(49.6%),heat-clearing drugs(10.3%),stasis-eliminating drugs(9.5%),Qi regulating drugs(7.7%), cumulative frequency up to 77.1%.medication Partial to warm,mainly to sweet taste;the drugs mainly into the liver meridian(20.4%),the spleen meridian (18.3%),the kidney meridian(16.7%);in drug combinations by cluster analysis, to mainly treat the RSA of deficiency of Qi and blood.In the statistical analysis of prescription of results during the modern times,medication to Chinese Angelica,Largehead Atractylodes Rhizome,Radix Glycyrrhizae,White peony Alba,Baical Skullcap Root;there is the larger proportion to replenishing drugs(43.7%),heat-clearing drugs(13.5%),Qi regulating drugs(12.6%),drugs for relieving exterior syndrome(10.2%),cumulative frequency up to 80.0%.medication Partial to warm and bland;mainly to sweet and bitter taste;the drugs mainly into the livermeridian(26.2%),the kidney meridian(22.6%),the spleen meridian(16.1%);in drug combinations by cluster analysis,to mainly treat the RSA of deficiency of kidney and spleen.(â…¢)ConclusionAnalysis from syndrome differentiation and treatment prescriptions' distribution of RSA indicates that there is higher using proportion and frequency for heat-clearing drugs,drugs for warming interior,Qi regulating drugs,mainly to replenishing drugs,medication Partial to warm and bland; mainly to sweet taste,the drugs mainly into the liver meridian;in drug combinations by cluster analysis,often involves four drug category such as replenishing drugs,heat-clearing drugs,drugs for warming interior,drugs for arresting discharge,with invigorating and consolidating the kidney and spleen,heat-clearing and nourishing yin,it reflects the feature of asthenia in origin and sthenia in superficiality and deficiency syndrome mingling with excess syndrome about cause and pathogenesis of disease and syndrome differentiation and treatment.Overall,about the concept of RSA,prescription of syndrome differentiation and treatment and the development process.â…¡The laws of syndrome differentiation and treatment of 30 recent years prescriptions(â… )Method20 recent years prescriptions'choice as VIP database for the main search way,with manual retrieval of books,screened important magazines,journals with the relevant experts and important books in recent 30 years reported in clinical literature of Chinese Medicine treatment of RSA.Standardize data, establish prescription database,and make analysis of frequency of use,cluster through the use of statistical methods to sum up its syndrome and treatment regularity of prescription. (â…¡)ResultsFrom the statistical analysis of the prescription of results of contemporary era,it is found that there is higher using proportion and frequency for replenishing drugs,heating-clearing drugs,exterior syndrome relieving drugs medication partial to warm and bland,mainly to sweet taste, the drugs mainly into the liver,spleen,kidney meridians.In drug combination by cluster analysis,it often involves four drug categories,such as replenishing drugs,heating-clearing drugs,exterior syndrome relieving drugs and drugs for arresting discharge.,with invigorating spleen and consolidating kidney,heat-cleaning and nourishing yin,promoting the production of body fluid to quench thirst.3 ConclusionAnalysis from prescriptions about RSA indicates that there is higher using proportion and frequency for replenishing drugs,heat-clearing drugs, drugs for warming interior,Qi regulating drugs,medication partial to warm and bland;mainly to sweet taste,the drugs mainly into the liver,the kidney,the spleen meridian;in drug combinations by cluster analysis,mainly involves drug category such as replenishing drugs,heat-clearing drugs,activating blood circulation drugs,with tonifing the liver and kidney and spleen, benefiting vital energy and nourishing yin,activating blood circulation to dissipate blood stasis,reflecting the feature of asthenia in origin and sthenia in superficiality,deficiency syndrome mingling with excess syndrome about cause and pathogenesis of the RSA,the laws of syndrome differentiation and treatment of replenishing healthy energy mainly and eliminating sthenia pathogenic factors.However,about the development and changes of ancient and modern prescriptions of the laws of syndrome differentiation and treatment,it is most significant that the using frequency of drugs replenishing drugs greatly increased.According to ancient and modern exposition and knowledge learning from Tutor Luo,the author discussed the female genital theory and the etiology and pathogenesis of RSA.To make the diagnosis of RSA comprehensive,systematic, clear;to make the treatment system that combines the disease and the syndrome in TCM more reasonable. |
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