Clinical Study Of Serum Testosterone And Androgen Receptors And Prostate Cancer Relations

Objective:To investigate the relationships of serum testosterone level,androgen receptor(AR) expressing in prostatic tissue and prostate cancer.Materials and methods:There were 75 cases who were firstly undergone 12-core prostate biopsy in Beijing hospital from April,2007 to April,2008.It was performed that pathological examinations of prostate tissue,immunohistochemical stain of AR,and serum testosterone levels of all cases.The statistic methods were used by independent t-test, chi-square test,Spearman non-parametric correlation analysis and ROC curve.Results:Serum testosterone levels were not significantly different(P=0.084)between BPH and PCa groups.In PCa group,there were no significant differences of serum testosterone levels in Gleason groups(P=0.433,P=0.481,P=0.813,) or in TNM staging groups(P=0.452) orin riskgroups(P=0.579) respectively.According to ROC curve,when the threshold of testosterone level was 5.445ng/ml,the PCa patients were divided into lower and higher groups.There were significant differences in PCa detection rate(P=0.040) and TNM staging(P=0.045) between two groups but no significant differences in PSA level(P=0.095) and Gleason scores (P=0.097).Testosterone levels were significantly different(P=0.031) in AR expressing groups,there were significant differences of AR levels in Gleason groups (P=0.015,P=0.017)but no significant differences in PSA level(P=0.990),major Gleason scores(P=0.978,P=0.339,P=0.470) and TNM staging(P= 0.856).Conclusion:lower testosterone level associates with higher incidence rate of PCa.In hormonal dependent phrase of PCa,higher level of AR expression associates with more invasive PCa.The serum testosterone level combining with PSA level, DRE and imaging examination will improve PCa detection rate.