Association Between Body Mass Index And Prostate Cancer Detection Rates In A Biopsy Population

Objectives: The objective of the current study was to analyze and find the relationship of the clinical characteristics of biopsy population in Huashan Hospital.Methods: From December 2004 to March 2008,406 males who underwent prostate biopsies in Huashan Hospital were reviewed retrospectively. Prostate cancer was detected in 192 cases. They were stratified by BMI into three groups according to the cutoffs recommended for Asian population: normal (BMI<23),overweight (23≤BMI<25),obese (BMI≥25).Variables analyzed included BMI, age, PSA , volume of prostate, biopsy result, and Gleason sun. T test, chi square ,K-W test, correlation analysis and logistic regression analysis were performed to find the relationship of the factors using SPSS.Results: Cancer patients was younger than non cancer patients, but it is not statistically significant (P=0.090). The prostate volume of cancer patients were smaller than those of non cancer patient (P=0.006). There was no relationship between age and prostate volume (P=0.406).There was no relationship between PSA and prostate volume(P=0.094).PSA was correlate with prostate volume in non cancer patient after controlling age (P=0.04). Among the men diagnosed with prostate cancer, no statistically significant association was found age and Gleason sum (P=0.314) . No significant differences were found in age between the three groups. After adjusting for age and PSA, prostate volume correlated with BMI (p=0.000).The cancer detection rate of obese group was much higher than that of normal group and overweight group. The conclusion still established in men with PSA<50.No statistically significant differences were observed between the groups (P=0.032).Prostate volume correlated with BMI in non cancer patients. But PSA had no association with BMI.Conclusions: younger patients with smaller prostate volume were likely to be diagnosed with prostate cancer. Age had no association with prostate volume and PSA. PSA was correlate with prostate volume in non cancer patient. A higher BMI was positively associated with being diagnosed with prostate cancer. Prostate volume correlated with BMI. But the clinical characteristics such as age, PSA, Gleason sum had no association with BMI. In non cancer patient, Prostate volume correlated with BMI in non cancer patients. But PSA had no association with BMI.