Experimental And Clinical Research On The Relationship Of Heat-Toxin And Thrombosis

Theoretical study elucidates that heat-toxin play an important role in the pathogenesis of acute coronary syndrome, it is the initial factor of thrombosis, and the target position is collateral. Hereby establish therapeutic principle of clearing heat, dispelling toxin and dredging collateral, and then validate the curative effect of Dispelling toxin and dredging collateral mixture on thrombosis through experimental and clinical research.Animal experiment observed the effect of Dispelling toxin and dredging collateral mixture on thrombisis. Carrageen used to make the tail thrombus model, measured the length of black tail at different time and examed the activeness of AT-III and the content of D-dimer, as well as the content of inflammatory factor IL-1β,TNF-α. Drew conclusion that Dispelling toxin and dredging collateral mixture had the function of alleviating the thrombus caused by carrageen. Through preventive administration, Dispelling toxin and dredging collateral mixture can decrease the value of IL-1βand TNF-α, inhibit the inflammatory reaction, also can enhance the activity of AT-Ⅲand reduce the content of D-dimer, thus alleviate thrombosis. The middle dose of Dispelling toxin and dredging collateral mixture is found the optimal dose to be effective.Clinical research observed the effect of Dispelling toxin and dredging collateral mixture on unstable angina. The control group,45 patients,treated with the routine therapy, while the test group,48 patients,added Dispelling toxin and dredging collateral mixture, treatment last for four weeks. The results show that Dispelling toxin and dredging collateral mixture has a very good therapeutic effect on unstable angina, and can alleviate the inflammation, improve the function of VEC, abate the blood mucosity and increase heart function. The other clincal research observed the intervention of Dispelling toxin and dredging collateral mixture on angina recurrence. The control group,14 patients,treated with routine medicine while the test group,20 patients,added Dispelling toxin and dredging collateral mixture, treatment last for three months. The results show that Dispelling toxin and dredging collateral mixture has curative effect on angina recurrence postoperation PCI, and can alleviate inflammation and adjust cruor and fibrinolysis.