| Nowdays, diabetes melitus (DM) is one of the most major public healthy questionsin the world. Diabetic retinopathy (DR) is one of the most common and importantmicrovascular complications of DM . At present, there aren't definitely effectivemedicine to fundamentally treat DM and DR on clinical treats. Based on the presentsituation and according to professor's experience of practicing, the thesis studied onDM and DR in foundation of project of NSFC. To discuss the mechanism of Chinesemedicine treatment on DM and DR from a new angle of nonenzymatic glucosylation inorder to find safe and effective Chinese medicine to treat DM and DR. The researchgives scientific supports for clarifying mechanism on preventing and treating otherchronic complications of DM, and then expands its clinical utilization scope.1 Clinical studyObjective:To Observe the effect of Donglian capsule in treating elderly patientswith type 2 DM and early DR. Method: The 90 patients who conform to the standardwere randomly divided into two groups: the 45 patients of the one group (treatmentgroup) were treated by Donglian capsule, and the 45 patients of the other group(contrast group) were treated by the Metformin Hydrochloride tablets. Syndromeswere scored and vision,fundus change,blood glucose,blood-lipid,HbA1c,GSP,AR were observed before and after treatment. Results: Type 2 DM and early DR inold patients were all improved in the two groups, and the total effective rate of thetreatment group and the contrast group were 51．3% and 37．8%. The total effectiverate of treated group was 60．3% while that of contrast group was 29．7% in DM , thetreatment group was significantly better than the contrast group (P<0．01) . Thetreatment group were better than the contrast group on syndromes and symptoms(P<0．01, P<0．05) . Blood glucose, HbAlc, GSP, TC, TG and AR can be lowered, whileHDL-C can be elevated by Donglian capsule. Conclusions: The curative effect ofDonglian capsule in treating elderly patients with type 2 DM and early DR wereaffirmatived. The treatment group was better than the contrast group in aspects ofimproving quality of life and DR pathological change, blood glucose, blood-lipid and decreasing activity of AR.2 Experimental studyObjective: To discuss the therapeutic effects and mechanism of Donglian onDR. Method:All rats were divided into 5 groups randomly, including normal group,model group, Metformin Hydrochloride tablets group and two groups with differentdose of Chinese herbal medicine. An animal model of DM was established byinjecting a little dosage ofSTZ in high fat-fed rats. When the model was establishedsuccessfully, corresponding medicine were supplied for 12 weeks and then the rats'weight,biochemical criterions, blood glucose, GSP and the content of NO, ET, hs-CRP,AR, IL-6, TNF-a in rats serum were mensurated. Rats' morphology and lesion of theretinal microvasculars were observed by light and electron microscope. Results: Theweight of diatetic rats were lower than that of normal group, and the results shows thatthe weight of treatment groups appear to be descending early and then ascendingfinally. The weight of Metformin Hydrochloride tablets group and a large dosage ofDonglian capsule group were obviously difference compared with model group(P<0．01, P<0．05) . Comparing with the model group, blood glucose, blood-lipid andother criterions' levels in Metformin Hydrochloride tablets group and Chinesemedicine groups were decreased markedly (P<0．05) . The NO level was higher andthe content of some cell factors in rats serum were lower in all treatment groups thanthe model group(P<0．05) , and the pathologic change in Chinese medicine groupswere slighter obviously after treatment with Donglian capsule than those in the modelgroup. Conclusions: Donglian capsule not only improve survival condition andincrease weight, but also intervene the development of DM. Donglian capsuledecreases the levels of blood glucose,GSP,ET and other cell factors in rats serum,enhances the content of NO and restrains nonenzymatic protein glycation to preventand treat DM.
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