Prevention Of Coronary Heart Disease Of Bushenhuoxue Square Efficacy Experiments And Anti-artery Atherosclerosis Mechanism

Objective: To study the pharmacology of BuShenHuoXue priscription in animal model of CHD and the mechanism of action on AS.Methods: In this experiment,the animals were divided into five groups of blank contrast,pathological models,high dosage,low dosage and medication contrast.After given drugs,examing hemodynamic response, lipid metabolism ,the change of blood flow,the change of sleeping, the action of antioxidizing and protecting the endothelial cell,. observing the wall of change of AS blood vessel.Results: BuShenHuoXue could make resistance of blood vessel,broad the coronaryartery,decrease oxygen consumption of myocarditis.improved the numbers of hemodynamics,reduced the range of cardiac infarction.The protection of heart deletion blood was owned. TG,T-CHO,RBC,LDL-C,CHO,VLDL,Apo,ET,LPOetr lower; the elevation of HDL,NO,SOD,SeGSHPx,LCAT etr.Increasing the period of sleeping on mice.Cellular degeneration and pathological damage was decreased.Increased PGI2 in blood and decreased TXA2 in blood.balancing the standard of the twe. Through increased SOD,SeGSHPx,it had an antioxidizing action.Conclusion: The protective action of BuShenHuoXue on the modle dogs of CHD, On the model of rabbits of AS.Its working mechanism is the result of muti-action on adjusting lipid metalism,blood flow,antioxidizing and protectiong the endothelial cell.