Several Topical Formulations For Treatment Of Acne Vulgaris Clinical And Laboratory Studies

In order to study and screen the effects of topical aplication of ofloxacin ( OFLX), spironolactone(SLT), ketoconazole (KCZ) and Tanshinone(TSN) on acne vulgaris. three stages of clinical trial were carried out in the thesis.In the first stage, five prescriptions such as:(1)1%OFLX cream,(2) 1%OFLX & 0.3% SLT cream, (3)1% OFLX & 2% KCZ cream, (4)2.5% TSN cream and (5)1% OFLX cream and 0.3% SLT cream used alternately were studied respectively on small samples. 1% OFLX cream and 2.5% TSN cream showed a better therapeutic effect. The next was 1% OFLX & 0.3% SLT cream. While the effects of 1% OFLX & 2%KCZ cream and the prescription of 1% OFLX cream and 0.3% SLT cream used alternately were disappointed.In the second stage, 1% OFLX cream. 1% OFLX & 0.3% SLT cream(1% OFLXco) and 2.5% TSN cream, which had been proven to be effective in the first stage, were studied further and sebum excretion rate(SER) was also measured simultaneously in some patients. Both 1% OFLX cream and 1% OFLXco cream were more effective on the inflammatory lesions with the response rates of 94% and 78. 85% respectively, while their effects on non-inflammatory lesions were slightly poor with the response rates of 81.25% and 62.5%. The results showed that there was no significant statistic difference between this two formulas. The effects on inflammatory lesions of 2.5% TSN cream were slightly superior to those on non-iflammatory lesions with response rates of 68.57% and 60% respectively. The results of statistic data showed that there were no significant difference between this two rates. In comparison with 1% OFLX cream and 1% OFLXco cream, 2.5% TSN cream was as effective as them. The SER of the patients treated with l%0FLXco cream or 2.5% TSN cream fell down notably at the end of the trial.In the third stage of the study, the results obtained in the second stage about 1% OFLX cream and 1% OFLXco cream were studied further on larger samples using an effective agent, 5% benzoyl peroxide cream (BP), as control. SER was also measured in some patients simultaneously. The effects of 1% OFLX...