Flavors Rheumatoid Capsule Drug Research

Mongolian drug Zhonglun-5 decoction is composed of Sophora flavescens Ait, Gardenia jasminoides Ellis, Terminalia chebula Retz, Viola yedoensis Makino. It is provided with the effect of heat clearing, removing heat from the blood. It can astringe and resist old heat, hidden heat, and cure feverish xiriwusu disease, severe migratory arthralgia, stagnation-symdrome of Qi and blood and the like. At present, it is mainly used in arthropathy and dermopathy caused by xiriwusu in clinic of Mongolian medicine.The traditional Mongolian drug zhonglun-5 decoction was developed into wuweifengshi capsules in this study. The best extractive technology is determined. The qualitative control criterion of wuweifengshi capsules is set up, and at the same time a study of its anti-inflammatory, abirritation, anti-rheumatoid arthritis action was made.A study of the best extractive technology was made with orthogonal design. The extractive technology of Sophora flavescens Ait used matrine and oxymatrine as the contrastive object while the other four drugs used gardenoside to test the content with HPLC. The experimental results showed the best extractive technology of Sophora flavescens Ait. was A1B3C2D2, namely eight times of 60% ethanol in quantity was decocted twice, ninety minutes each time. The best extractive technology of the other four drugs was A₂B₁C₂, namely eight times of water in quantity was added, decocted twice, sixty minutes each time.A qualitative identification of Sophora flavescens Ait, Gardenia jasminoides Ellis, Terminalia chebula Retz, Viola yedoensis Makino was made with thin layer chromatogram. The content of matrine and oxymatrine was tested with HPLC. The experimental results showed that the characteristic spots of each drug in the chromatogram of thin layer are clear and distinct. The reappearance is good. The content determination method is practical, recovery of matrine plus oxymatrine, gardenoside were 101.2% and 98.32%, RSD...