| Total flavonoids of epimedium is one of the effective compounds from Epimedium Koreanum Nakai. In the previous study, it had been showed that the capsule of total flavonoids of epimedium(Huo Tong Jiao Lang) posseses good effect for anti-myocardial ischemia. Epimedium flavonoids injection(EFI)was explored to reduce the dose of total flavonoids of epimedium, and to effect more quickly for the crisis of coronary heart disease. It was separated into two parts in this study. First, the general pharmacodynamics of EFI on anti-myocardial ischemia was experimented. Second, the mechanism of EFI on anti-myocardial ischemia was explored through neonatal rat cardiomyocytes cultured in vitro.Partâ… Pharcodynamic study on anti-myocardial ischemia of epimedium flavonoids injectionGeneral pharmacodynamics of EFI on anti-myocardial ischemia through different ischemia model (induced by pituitrin and ligating the left anterior descending coronary artery separatly) in different animals (including rats and dogs). At the same time, the effects of EFI on the hemodynamics and myocardial oxygen consumption index were studied in the normal anaesthetized chest-open dogs.一,Effects of epimedium flavonoids injection onexperimental myocardial ischemia induced by pituitrin in rats To explore the protective effects of epimedium flavonoids injection (EFI) on experimental acute myocardial ischemia induced by pituitrin(Pit)in rats. The rats were divided into 7 groups which were control, model, positive drug(nitroglycerin, NG, 0.3 mg/kg ) , and EFI of 10,20,40,60 mg/kg. Drugs were injected by intravenous injection (iv), whereas 5% glucose injection were given to the rats of control and model. 5 minutes later, the ischemia model was established induced by 1.5 IU/kg Pit through intravenous injection. Recording ECG for 1 minute before iv Pit and for 15min after iv Pit. The changes of ECG ST-T and heart rate were detected by using Acq3.7.2 Image Analysis Software. It was showed that...
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