Patients With Pet Functional Brain Imaging Study Of The Liver Qi Stagnation And Chinese Medicine Neuroinformatics Study,

1 Clinical research part-the study on the stagnation of Liver-Qi syndrome using brain functional imaging techniques with PET1.1 Objectiveto explore the possible changes in the brain functional imaging of the stagnation of Liver-Qi syndrome involved in multi-diseases and try to find the rules of these changes1.2 MethodsWe chose the subjects according the authorized diagnosis criteria of the stagnation of Liver-Qi syndrome and then paired them with control group which in the similar condition but without the stagnation of Liver-Qi syndrome. All the subjects including the control group were scanned under PET (Ecat Exact HR , Siemens production) after the injection of FDG without any cognition task. The results of brain imaging were analyzed and the statistics of data was performed with the special software SPM v99.1.3 ResultsFor the subjects of the stagnation of Liver-Qi syndrome compared with the control group, the metabolism of glucose decreases in the following brain sections (PO.01): Brodmann area 47, Cingulated cortex, Brodmann area 21, Brodmann area 6, Brodmann area 37 and 38 of both sides, Brodmann area 4 and 6. While the metabolism of glucose increases in the area of mesocephalon, the area of the borderline of medulla oblongata, Brodmann 18 area and the left cerebellum.1.4 Conclusions1.4.1 the conclusions in the brain functional imaging of the stagnation of Liver-Qi syndrome using PET:For the subjects of the stagnation of Liver-Qi syndrome involved in multi-diseases, the metabolism of glucose is abnormal in some brain sections (P<0.01). This abnormity reflects the maladjustment of the brain lobs.The common symptom -the disorder of emotion, both in the stagnation of Liver-Qi syndrome and the depression, is caused by the dysfunction of themetabolism of glucose in the correlative brain sections.1.4.2 The close relation between the Liver and the brain makes up the theoretic foundation of studying the stagnation of Liver-Qi syndrome by brain functional imaging using PET.1.4.3 The diagnosis criteria of the stagnation of Liver-Qi syndrome should include two parts-the disorder of emotion and the symptoms occurring along the Liver Channel. Other symptoms are dispensable and not special for the diagnosis criteria. But they can help to diagnose. Furthermore, the kernel symptom of the stagnation of Liver-Qi syndrome is the disorder of emotion, which consists with the depressive status.1.5 SummaryThe main symptom of the stagnation of Liver-Qi syndrome is the disorder of emotion, which is proved that it is correlated with the disfunction of the brain. These indicate that the substance of the stagnation of Liver-Qi syndrome is the disorder of emotion caused by the dysfunction of the brain.2 Theoretic research part-the discuss of Neuroinformatics of TCM2.1 Objectto discuss the feasibility of establishing the new subject of neuroscience -Neuroinformatics of TCM, and to describe the conception of it2.2 MethodsBy studying the recent development of the neuroscience, the Human Brain Project and the Neuroinformatics, we discussed the background of establishing Neuroinformatics of TCM and the necessity of studying it, described its conception, its aims, its developing plans, its research directions, its varied content and so on.2.3 ConlutionsNeuroinformatics of TCM is a new subject of neuroscience given birth by the close combination of TCM and Neuroinformatics. It is a part of neuroscience that studies TCM with the methods of neuroinformatics, such as brain imaging techniques. It is not only a part of Neuroinformatics, but also a part of the research of TCM. It is the breakthrough or cut-in for China to engage in the research of Human Brain Project and Neuroinformatics.2.4 SummaryIn brief, Neuroinformatics of TCM is a new subject of neuroscience with two research aims, three development plans, four research directions and varied research content.