| Diabetic nephropathy (DN) is an important microvascular complication of diabetic mellitus (DM) as well as the common reason resulting in chronic renal failure. Now, DN has been the first reason resulting in end-stage renal disease (ESRD), about 35% of which are caused by DN. Systematic studies on the prevention and treatment for DN by JieDuTongLuoBaoShen capsule (JDTLBS capsule) had been performed from the aspects of reference reviews, theory and experimental study in this essay. It layed stress on exploring the relation between the inflammatory pathogenesis of DN and the pathogenesis theory of the damage of kidney by poison and discussing remedial advantages of JDTLBS capsule from intervening inflammatory pathogenesis of DN. "Method of Removing toxicity, removing obstruction and supplementing kidney" being scientific is clarified from different aspects ulteriorly. The experimental study clarifies pathological mechanism of DN ulteriorly from herb restraining expressed pathway of inflammatory factor, which is practical and innovative . 1 Reference review 1.1 The skeleton research of traditional Chinese medicine (TCM) on DN This essay reviewed from the advances of such fields as followed: the source and name of TCM for DN, the etiology and pathogenesis for DN, selection of treatment based on the differential syndrome diagnosis , pathogenesis of TCM on DN, which is in ancient and modern times, moreover, included the evaluations and prospects on the criterions of diagnosis and curative effect as well as the problems lying in the selection of treatment based on the differential syndrome diagnosis or scientific study. 1.2 The latest study of inflammatory pathogenesis of DN The results and progresses of study on the monocyte chemoattractant protein-1 (MCP-1), the nuclear factor-κB (NF-κB) and angiotensin II (AngII ) were summarized involving the inflammatory pathogenesis of DN recent years. 2 Theory Study By discussing the pathogenesis theory, principle and method of treatment of Xiao ke nephrosis with Chinese medicine theories quoting from classics works and combining modern research result, we put forward and perfect the theory that the main mechanism of Xiao ke nephrosis is the damnification of Kinney by poison and we also clarify the relation between the inflammatory pathogenesis of DN and the pathogenesis theory of the damage of kidney by poison. Theory gist of treating Xiao ke nephrosis is provided by us from discussing the effective way of "Method of Removing toxicity, removing obstruction and supplementing kidney" intervening inflammatory pathogenesis of DN. 3 Experimental study 3.1 The influence about JDTLBS capsule on the renal function in experimental diabetic rats STZ-induced diabetic rats were divided randomly into normal control group, diabetic model group, positive control group (DM+Benazepril), experimental group (DM+JDTLBS capsule) in Chinese herb. The various marks were observed. The results showed JDTLBS capsule obviously improve the rats' general condition and had a certain effect on reducing blood sugar, serum cholesterol (TC) and triglyceride (TG), low density lipoprotein (LDL) and increasing high density lipoprotein (HDL-C) , which had a significant statistic sense in comparing with diabetic model group (P<0.01, P<0.05). Besides it could inhibit renal hypertrophy in early stage and high filtration of renal glomerulus as well as decrease the experimental rats' higher serum urea nitrogen, creatinine, endogenous creatinine clearance rate, which had a significant difference against diabetic model group (P<0.05, P<0.01). It also reduced the experimental rats' urinary protein amounts and urinary albumin excretory rate (UAER) in 24h, having a markedly difference against diabetic control group (P<0.01). The results indicated that JDTLBS capsule was beneficial for regulating glucose and lipid metabolism, inhibiting renal hypertrophy and high filtration of renal glomerulus, reducing the urinary protein excretion, improving renal function. 3.2 The influence about JDTLBS capsule to the chan...
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