| Objective: To study the TCM(traditional Chinese medicine) mechanism on chronic fatigue syndrome(CFS),and investigate the epidemiology, the character of TCM syndrome on CFS in Hongkong and the result of Chinese herb curing the disease.Methods: Based on reviewing and summing-up the discussions and research reports on CFS in the ancient and modern literatures, the content includes ancient TCM literature discussing fatigue, etiology and pathogenesis, syndrome character, preventive and therapeutic rules, and treating methods, et al. In addition, based on diagnostic rule constituted by American Control Disease Center (CDC) in 1994 and fatigue scale constituted by Trudie Chalder in England, set up " 20-50 years old person's fatigue condition inquiry questionnaire in Hongkong" part one making an epidemiology inquiry. According to the persons who meet with CFS diagnosis standard in the questionnaire and TCM syndrome guidance in "new medicine in Chinese herb on clinic research directions" , set up the questionnaire part two making a TCM syndrome inquiry. In part three, aiming at CFS using Chinese herb to cure, investigate on fatigue symptom score's difference and efficient quotiety in treatment group and control group before and after treatment.Results: Theoretical research: CFS is smilar to the symptom "xieduo", "xiedai" in TCM. The pathogeny is mainly related to over physical work , over brainwork, excessive sexual intercourse, improper diet and congenital deficiencies. The main pathogenesis is related to deficient spleen, stagnation of the liver-Qi, deficiency of the kidney,blood stasis.The emphases in treatment is to nourish Qi, smooth the liver and promote blood circulation. The retrospective study on CFS in nearly past ten years' literatures shows that in many syndromes the deficiency of Qi and blood stasis are the most ones.In the deficiency of Qi syndrome, deficiencyof blood and blood stasis are the most.Clinic research: In the questionnaire part one, randomly investigate 1013 cases of 20-50 years old person in Hongkong, concluding no fatigue 213, account for 21 percentage; slight fatigue 215, account for 21.2 percentage; common fatigue 310, account for 30.6 percentage; prolonged fatigue 92, account for 9.1 percentage; idiopathic fatigue 118, account for 11.6 percentage; CFS 65, account for 6.4 percentage. From above, the disease occurrence rate is 6.4 percentage, which accords with CFS diagnosis standard. The ratio of men to women is 0.77 : 1, which the disease occurrence rate of men is lower than that of women, but there is no difference between them(P>0.05). Compared with three age group(20-30,31-40,41-50),there is no difference(P>0.05). However, there is difference in education degree(P<0.05). In the questionnaire part two, 56 cases according with the CFS diagnosis standard are made a face to face visit. The result shows: depression of liver and deficiency of spleen 2 cases, account for 3.6 percentage; deficiency of Qi and blood 4 cases, account for 7.1 percentage; deficiency of Qi 3 cases, account for 5.4 percentage; deficiency of Qi and stasis of blood 20 cases, account for 35.7 percentage; deficiency of kidney-yin 7, account for 12.5 percentage; deficiency of kidney-yang 18, account for 32.1 percentage; excess of damp-heat 2 cases, account for 3.6 percentage. In the questionnaire part three, there are 31 cases in the treatment group. There are 3 cases in obviously effectiveness, 25 cases in effectiveness, 3 cases in no effectiveness, and the total effective ratio is 90.32 percentage. The symptom score is 59.39 ± 19.10 before treatment, and 29.03 ± 10.90 after treatment. There are 25 cases in the control group. There are 0 cases in obviously effectiveness, 2 cases in effectiveness, 23 cases in no effectiveness, and the total effective rate is 8.00 percentage. The symptom score is 59.36 ± 18.12 before treatment, and 58.79 ± 11.07 after treatment. There are obvious difference in effective rate and symptom score between two groups.Conclusion: There is high disease occurrence rate in 20-...
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