Kidney Strong Governor Treatment Of Ankylosing Spondylitis In Patients With Clinical Research And The Mechanisms Discussed

Ankylosing spondylitis(AS) is a chronic inflammatory whole body disease whichmainly involves axis joints and insertion site including muscle tendon,ligament andbone.Its characters are inflammatory waist pain,muscle tendon inflammation,peri-Arthritis and manifestation out of joints.AS mainly attacks sacroiliac joints,spineand limb joints.It results in calcification of joints and tissues,ligaments,Inter-vertebral discs around joints.At last it will develop to bony ankylosis.At presentAS' etiological factor isn't clear.It results in absence of aiming treatment andunsatisfactory in effct.Recent years we use "reinforcing the kidney and streng-thening Du" recipe to treat AS patients,which professor Yanxiaoping summaries onthe basis of many years clinic experience. Clinic and experimental research makeclear that this recipe has satisfactory effct in curing AS patints.We think"deficience of kidney and Du,wind,cold and moist deeply invading kidney and Du" isthe main TCM etiologic factor and pathogenesis. "Reinforcing the kidney andstrengthening Du" is the basic technique.On the basis of prophase studies,thissubject emphasized on standardizing in clinic research and studies of this recipe'seffect and mechanism to AS patient's cellular immunity function. The literature and theory research section rather entirely collected TCM andwest medicine research evolving about AS in resent years.By colligating studyachievements of civil and oveseas scholars,the pathogeny and mechanism relate tomany factors such as heredity,immunity,endocrine and circumstance.Advancedstrengthening the studies in pathogeny of AS has very important significance tosearch efficiency therapy.AS is a modern medicinal name.It belongs to blockagesyndrome of TCM.There are not clear records of AS in TCM antient medicinal books.Butmany descriptions about "kidney blockage","bone blockage","intractable blockage","acute arthritis","waist pain" are resemble to AS in past dynasties medicinalbooks.These literatures provide very important tutor significance to our treatmentin AS.Modern TCM scholar process a great deal of helpful research work on AS'pathogenyand mechanism,diagnosis and treatment based on an overall analysis of the illnessand the patient's condition. But present researches are absent of consolidatedunderstand and standard. It takes many oppugns and challenges to the validity andsecurity of TCM diagnosis and treatment.It goes against development instandardization and reliability of differentiation of syndromes.4 补肾强督方治疗强直性脊柱炎患者的临床研究及机制探讨 The clinic study aimed at evaluating the curative effect of "reinforcing thekidney and strengthening Du" recipe.We established a relatively objective effectassessing method on the basis of international rather versatile effect assessingcriterion.Our aim was to promote the transformation from experience medicine toevidence-based medicine(EBM).After treatment, 60 AS patients' sympotoms,physicalsigns and laboratory indexes were ameliorated very well.Analysis of this recipe'curative effect show:This recipe' general available rate was 95.0%.Clinic remissionrate was 30.0%.Apparent available rate was 33.3%.Available rate was 31.7%.Ineffi-cient rate is 5.0%.These prove that "reinforcing the kidney and strengthening Du"recipe has satisfying curative effect to AS patients. The experimental study adopted Immunohistochemical method,Elispot method andreverse transcription polymerase chain reaction(RT-PCR) method,in order toinvestigated the cellular immunal function changes of AS patients and the adjustmenteffct to these by "reinforcing the kidney and strengthening Du" recipe.In AS patientsPBMC, CD4+ cell, CD8+ cell,CD4+/CD8+,Th2 cell and IL-4mRNA had no distinct differencefrom normal people.But Th1 cell,Th1/Th2,IL-18mRNA,IFN-γmRNA had distinct hoistingand were evidently ameliorated after treatment by "reinforcing the kidney andstrengthening Du" recipe.These...