| Sports anemia is a phenomenon that average hemoglobin and red blood cell level under normal value respectively for sports training or contest. Sports anemia is a general state of poor sports ability during sports training. And occurrence and development of sports anemia is one main factor affecting sports ability of athletes, especially athletes of physical fitness items. Iron is the required microelement supporting life, and its biological functions in body as follow: control carrying and storing oxygen by compose hemoglobin, participate in energy metabolism by form respiratory chain, constitute some enzyme as co-factor, form synthesis of protein. At present, the mechanism of sports anemia is pending investigated, effects of sports training on iron metabolism and effects of iron metabolism turbulence on sports anemia is at a loss. Meanwhile there are not animal model of sports anemia, which limit the mechanism research of sports anemia.The experiment started establishing repeatable animal model of sports anemia, investigated the character of iron metabolism and some indexes that reflecting iron metabolism when sports anemia happened. And anti-anemia iron compound nutrition was administrated and the treatment effect and iron metabolism were observed in both animal and human, In addition, the function of iron metabolism during sports anemia and delicacy indexes reflecting iron metabolism were explored. Furthermore, the research would perfect theory of sports anemia and provide evidence for searching better nutrition method of prevent and treatment.Part one Animal experiment1. 5 weeks treadmill exercise of increase by degrees decreased blood hemoglobin level (P<0.05). Meanwhile, subsequent 6 weeks exercise maintained the condition of sports anemia in rats. The animal model of sports anemia was established successfully and possessed repeatable character.2. The exercise induced iron metabolism turbulence in the rats of sports anemia. Serum iron and tissue iron distribution had different changes such as serum iron and bone marrow iron significantly decreased, liver iron and muscle iron significantly increased, and brain iron, cardiac muscle iron and spleen iron had not significantly changes. The different changes possibly were characteristic changes during sports anemia term induced by sports training. In addition, the iron metabolism turbulence was one important factor of generation of sports anemia.3. Sports anemia caused cuprum metabolism turbulence such as distribution of serum cuprum and tissue cuprum had different changes and effects of sports training on tissue cuprum possessed position characters. And the changes of cuprum and iron were not synchronization.4. The results of iron metabolism of sports anemia in rats as follow: sports training increased serum ceruloplasmin and transferrin significantly, sports training increased erythrocyte zinc protoprophyrin and transferrin receptor of erythrocyte membrane significantly, these indexes relating with serum iron strongly indicated that serum ceruloplasmin, ferritin, transferrin could reflect iron metabolism, and erythrocyte zinc protoprophyrin and transferrin receptor levels could reflect iron metabolism in erythrocyte. And organic combination of the indexes reflect iron metabolism accurately.5. Expression of transferrin and transferrin receptor in sports anemia rats induced by sports training had position characters, and expression of transferrin receptor had significant relation with iron metabolism in tissue.6. Anti-anemia iron compound nutrition increased serum iron, bone marrow iron and retarded the development of tissue iron induced by sports training.7. Anti-anemia iron compound nutrition decreased serum ceruloplasmin and transferrin, erythrocyte zinc protoprophyrin and transferrin receptor of erythrocyte membrane significantly, and increased serum ferritin level. In addition, the indexes could reflect positive functions of anti-anemia iron compound nutrition on iron metabolism.8. An... |
PDF Full Text Request