| Objective: To observe the therapeuc effect and explore the mechanism of Youweikang (YWK) in treating Chronic Gastritis with I-Ielicobacter Py- ion Infection (HPCG). Methods: 97 cases of HPCG were divided into two groups randomly. The treatment group (50 cases) was treated with YWK o- rally and the coiiIrOl group (47 cases) was treated with Weifuchun (WFC) orally. The clinical and pathological effects were observed during the course. The expcriment was designed to observe YWK influence on chronic gastritis rats model in the content of serum IL ?8, gastric mucosa PGE2, cAMP, cGMP, SOD, MDA and histopathology. Results: The clinical study has showed that the best rate and total rate in treatment group were 36% and 94% ,while in control group were 21. 28% and 85. 11% respectively. The difference was significant (P < 0. 05). The clinical study has also showed that YWK could improve the inflammation of gastric mucosa, clear Helicobacter Pylon (H. pylon ) and reverse atrophic gastric mucosa, in- testinal met aplasia and atypical hyperplasia. The animal experiment study showed that YWK could reduce the content of IL-8 and MDA significantly, increase the content of PGE2, cAMP and SOD, increasing cAMP/cGMP val- ue of gastric mucosa, improve gastric emptying. Conclusiom: YWK was an effective drug in treating J-IPCG. The mechanism might be realized by anti- inflammation, anti-toxidation, protect gastric mucosa and improve gastric emptying...
|
PDF Full Text Request