| The article aim at trying to find the pathology rule of atrophydisease by the clinic observation analysis,moreover to find apreferably ways to treat the disease． Because the atrophy disease related to many pathlogical changes,having varies manifesting in clinic, so its dominant pathologymechansims not one kind；we must study it by sorts． By comparing,we think the ideal ways of questing for the ruleof TCM treating by differenttations,is starting with the diseaseof which manifested the main syndromes of muscle atony, and haverandom comparison with enough cases,but with the limit of time andresearch conditions,we have to choose one kind disease -Amyotrophic lateral sclerosis(ALS)to study． Through the analysis of ancient article andthe present studyof atrophy disease,we found thoughvarles doctors or scholars havequite detail theory about the etlology＼pathology＼treating law andrecipes,but they are not agree with each other,nobody can makeothers believe him by enough science proof．So all we do was basedon the knowledge． by the complete analysis of 120 ALS clinic data, we thoughtthe rules of pathology change is spleen qi deficiency - liver andkidney yin deficiency-phlegm, dampness and blood stasis formed-die. The clinic observation of 32ALScases treated by recipe ofstrengthen the spleen and kidney showthat the recipe can improvethe syndromes andtough and pulsepathologychanges,flesh于orce；decreasethe contain of glutamlc acid In brain and spine fluid,improve the nerve movement passingveloClty,decreasetheappearingratio of bundle quivering electricity digit, The study prove ourtheory of the pathology changes rules and treating discipline is 4correct on one hand,and on the other hand It prove our recipe ofstrengthening the spleen and kidney is effective and safe, whichcontribute to the treatment of the atrophy disease. Because of the complexity of its pathology and the difficultyof curing it , there are many proiblems about research work to besolved.
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